Objective: To investigate the etiology of Major Depressive Disorder(MDD), we explored the relationship of anhedonia, stress and neuroticism in MDD patients. Methods: Investigation was conducted among 84 MDD patients and 75 healthy controls by using the Temporal Experience of Pleasure Scale(TEPS), Five-Factor Inventory-Neuroticism(FFI-N), Beck Depression Inventory(BDI) and Live Events Scale(LES). Results: Compared with healthy controls, MDD patients exhibited significantly lower scores on anticipatory pleasure, consummatory pleasure(P<0.05) and higher scores on neuroticism, BDI and stress(P<0.05). Logistics Regression analysis showed that consummatory pleasure(OR=1.10, 95%CI=1.03-1.17), neuroticism(OR=0.91, 95% CI=0.83-1.00), BDI(OR=0.93, 95% CI=0.89-0.98) and negative life events(OR=0.94, 95%CI=0.92-0.97) had significant impact on MDD patients. Conclusion: These findings suggest that consummatory pleasure, negative stress, neuroticism are risk factors in Major Depressive Disorder.
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