中国临床心理学杂志

抑郁症患者自动思维与识别情绪词诱发ERPs的相关研究

作者：姚树桥² 吴大兴² 梁宝勇¹ 郭文斌²

单位：1. 天津师范大学心理与行为研究中心天津 300073
2. 中南大学湘雅二医院

分类号：R749.4

出版年,卷(期):页码：2003,11(3):192-194

摘要：

目的：探讨抑郁症患者自动思维、抑郁情绪与识别情绪词诱发ERPs的关系。方法：采用Hollon等编制的自动思维问卷(ATQ)评价负性认知偏差程度，Zung’s抑郁自评量表(SDS)评价抑郁严重程度。同时神经扫描仪(Neuroscan)记录16名抑郁症患者视觉语义鉴别汉字情绪词的事件相关电位(ERPs)。情绪词分为三组，其中正性词40个、负性词40个，中性词120个。结果：(1)ATQ评分与负性词FZ、F3、F4点N350波幅、正性词CZ的N650波幅负相关(r=-0.514～-0.614，P<0.05）。(2）SDS评分与正性词FZ点N250波幅正相关(r=0.52，P<0.05）；与正性词F3的N350、负性词的F3、F4的P490潜伏期负相关(r=-0.503～-0.596，P<0.05），与负性词CZ点的N650潜伏期正相关(r=0.615，P<0.05）。结论：抑郁症患者自动思维、抑郁情绪与识别情绪词诱发ERPs之间存在一定程度相关。

Objective: To investigate relationship between automatic thoughts, degree of depression and event-related potentials(ERPs)stimulated by Chinese emotional words in patients with major depression.Methods: Automatic Thoughts Questionnaire(ATQ)and Self-Rating Depression Scale(SDS)were used to assess the automatic thoughts and degree of depression respectively, and the effect of the Chinese emotional words on ERPs were measured in 16 major depression patients. Three lists of words including 40 positive words, 40 negative words,and 120 neutral words were used as stimuli.Results:(1)ATQ scores were negatively correlated with N350 amplitude stimulated by negative words in FZ, F3 and F4(r=-0.514～-0.605, P<0.05). ATQ scores were also negatively correlated with N650 amplitude stimulated by positive words in CZ(r=-0.614,P<0.05).(2)SDS scores were positively correlated with N250 amplitude stimulated by positive words in FZ(r= 0.52, P<0.05), negatively correlated with N350 latency stimulated by positive words in F3(r=-0.534, P<0.05), negatively correlated with P490 latency stimulated by negative words in F3 and F4(r= -0.596,-0.503, P<0.05), and positively correlated with N650 latency stimulated by negative words in CZ(r=0.615, P<0.05). Conclusion: The findings suggest that the automatic thoughts and degree of depression are significantly relative with some components of ERPs elicited by the Chinese emotional words eliciting in patients with major depression.

基金项目：

教育部人文社科重大研究项目资助(2000ZDXMXLX004)

作者简介：

参考文献：

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