中国临床心理学杂志

抑郁症患者血中T细胞亚群数量及相关因素的研究

作者：汤艳清¹ 2 谢光荣³ 李艳苓⁴ 冯晓红⁵

单位：1. 中国医科大学医学心理学教研室辽宁沈阳 110001
2. 中南大学湘雅二医院湖南长沙 410013
3. 中南大学湘雅二医院湖南长沙 410013
4. 鞍山市中心医院心理科
5. 鲁迅美术学院学生处

关键词：抑郁症 T细胞亚群细胞免疫

分类号：R395.2

出版年,卷(期):页码：2004,12(3):279-280

摘要：

目的：研究抑郁症患者外周血中T细胞亚群的变化及相关因素，探讨抑郁症患者的免疫功能变化，为治疗提供新的依据。方法：应用碱性磷酸酶标记链霉卵白素法检测32例抑郁症患者和32例健康对照血中T细胞亚群数量及构成比，并与其相关因素进行多元线性回归分析。结果：1.与对照组相比，抑郁症患者血中CD3⁺ 、CD4⁺ 细胞数以及CD4⁺ /CD8⁺ 比值明显降低，而CD8⁺ 细胞数明显升高。2 .男性患者与抑郁症患者总体改变相同。而女性患者血中CD3⁺ 、CD4⁺ 细胞数、CD8⁺ 细胞数以及CD4⁺ /CD8⁺ 比值与对照组比较差异不显著 ;3.多元线性回归结果：抑郁症患者血中CD8⁺ 细胞数与病程呈非常显著负相关。结论：抑郁症患者免疫功能低下，其免疫功能低下可能有性别差异，而且抑郁症患者的免疫功能变化可能与病程有关。

Objective:To explore the cause and pathological mechanism of depression by detecting the number of T cell subpopulation in patients?? venous blood.Methods:3 depression patients and 3healthy persons of matched ages as normal controls were selected for the study.The numbers of T Cell subpopulations and their component ratio i.e.the numbers of CD3⁺ cells, CD4⁺ cells and CD8⁺ cells and the ratio of CD 4⁺ / CD 8⁺ cells in their venous blood were detected by SAP method.Results:(1) As compared with that of the controls, the numbers of CD3⁺ and CD4⁺ Cells and the ratio of CD4⁺ / CD8⁺ decreased, while the number of CD8⁺ cells increased obviously in blood of depression patients.(2) The change of male patients were similar to the general change of depression patients; while there were no significant change in the numbers of CD3⁺,CD4⁺,CD8⁺ and the ratio of CD4⁺ / CD8⁺ in female patients.(3) The multifactor linear regression analysis showed that the number of CD8⁺ cells was significantly negatively correlated to the disease course.Conclusion: Severe immune function disorders were found in depression patients, with difference in sex, and that disorder may be related to the disease course.

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参考文献：

[1] Maes M,et al.Multiple reciprocal relationships between in vivo cellular immunity and hypothalamic-pituitary-adrenal axis in depression.psychological Medicime,1994,24:167-177
[2] Tracy BH, et al Depression and Immunity : A meta-analytic Review .Psychological BilletiI1.1993,113:472-486
[3] Maes-M, et al.Immune disorders in depression :Higher T helper/T suppressor-cytotoxic cell ratio ,Acta-psychiatr-Scand.1992Dec,86(6):423-43l
[4] 迟松,林文娟.抑郁症神经内分泌学的研究进展及心理治疗的作用.中国临床心理学杂志,2003,11(1):77-80
[5] Grossman CJ.Regulation of the immune system by sex steroid.Endoer Rev 1984,5:435-454
[6] Homo-Delarche F, Durant S.Hormones neurotransmitters and neuropeptides as modulators of lymphocyte functions.In : Rola-pleszczynsknski M (ed) Immunopharmacology of lymphocytes.Academic Press Limited ,London ,1994,169-240

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