中国临床心理学杂志

抑郁症的脑结构影像学改变及其机制的研究进展

作者：汤艳清¹ 2 谢光荣¹

单位：1. 中南大学湘雅二医院精神卫生研究所湖南长沙410011
2. 中国医科大学精神卫生教研室辽宁沈阳110001

关键词：抑郁症脑结构影像学

分类号：R749.4

出版年,卷(期):页码：2005,13(3):366-369

摘要：

抑郁症的核心症状是情感的障碍以及认知功能的改变，但这些改变的神经生物学机制至今仍不清楚。大量的研究表明抑郁症患者存在神经解剖环路(边缘系统—皮质—纹状体—苍白球—丘脑环路)的功能异常，尤其是额叶皮质、杏仁核和海马。本文将综述边缘系统—皮质—纹状体—苍白球—丘脑环路以及抑郁症在这—神经解剖环路的变化，其中主要闸述海马、杏仁核和额叶皮质的变化，还将探讨早期、反复发作抑郁症脑结构变化的可能的机制以及抑郁症是脑结构异常的原因还是结果的问题。

The main symptomes of depression are mood disorder and the changes of recognitive function. But it is un-clear for the mechanism of neurobiochemcal. Many studies revealed that there are abnormalities function in neuroanatom-ical circuit (limbic-cortical-striatal-pallidal-thalamic tract especially in frontal cortex、hippocampus and amydala). This article will briefly review this neuroanatomical circuit and the changes of brain structural of this circuit in depression. The changes of frontal cortex、hippocampus and amydala will be mainly explored. Finally, potential mechanisms for structural brain abnormalities in depression will be discussed and the question of whether depression is the cause or effect of abnor-malities in brain structure will be addressed. I wish it can give some ideas for the future study.

基金项目：

作者简介：

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