中国临床心理学杂志

海洛因成瘾者停用海洛因后的脑功能情况——静息状态下fMRI研究

作者：王绪轶¹ 郝伟¹ 颜丽蓉² 胡德文² 刘铁桥¹ 谌红献¹ 向小军¹ 张登科¹

单位：1. 中南大学湘雅二医院精神卫生研究所湖南长沙 410011
2. 国防科技大学机电工程与自动化学院湖南长沙 410073

分类号：R395.2

出版年,卷(期):页码：2006,14(4):428-430

摘要：

目的:探讨海洛因成瘾者停止用药后静息状态下脑功能的变化情况。方法:对海洛因成瘾者在停止使用海洛因3天(10人),1个月(10人)以及2个月(14人)时分别在静息状态下进行功能磁共振检测。并与正常对照进行比较。结果:成瘾者停用海洛因3天时出现额叶内侧,扣带回,颞上回等异常,停用1个月,额叶脑功能异常加重,海马功能出现异常,停用2个月,脑功能逐步恢复。结论:脑区的变化可能反映出海洛因成瘾者停药后渴求和复发可能性先增加,再下降的变化过程。额叶和海马发生变化时有时间上的关联性。本研究结果一方面为成瘾的动机假说提供了新的支持,另一方面提出海洛因依赖者在停药1个月左右复发的风险最大。

Objective:To study the brain functional changes in heroin dependent patients at conscious resting state during 3 days(n=10),after one month(n=10),tafter two months(n=14) after getting rid of the drug use.Methods:We investigated the resting brain function with fMRI in three groups of heroin dependent patients and 12 normal controls.10 heroin addicts were tested 3 days after the last use of heroin;10 heroin addicts were tested 1 month after the last use of heroin;14 heroin addicts were tested within 2 months after the last use of heroin.Results:Compared with controls,the heroin addicts had significant(P＜0.05)BOLD signal in Medial Frontal Gyrus,Cingulate Gyrus,and Superior Temporal Gyrus in 3 days of abstinence.Frontal lobe deficits were further worsened and the hippocampus began to be abnormal one month after withdrawal;all the dysfunction of above-tended mentioned to become normalized two months after abstinence.Conclusion:This study shows that the function of resting brain in heroin dependent patients follows a similar U-shaped curve after withdrawal.It probably means that the intensity of craving and the possibility of relapse in heroin addicts have the same change pattern after withdrawal.In addition,the results of the study,which show the time causal relationship between worsen functioning in frontal lob and the abnormity in hippocampus,provide the new evidence of motive theory of drug addiction.

基金项目：

国家973项目(项目号:2003C5154004);国家自然科学基金(项目号:30370522)

作者简介：

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