中国临床心理学杂志

首发抑郁症患者新异Oddball模式下P300波形特征研究

作者：吕静苗丹民贡京京王家同

分类号：R395.1

出版年,卷(期):页码：2008,16(3):230-233

摘要：

目的:通过分析首发抑郁症患者在新异Oddball模式下诱发出的P300波形特征,探讨抑郁症患者的认知过程。方法:选取未治疗的青年抑郁症患者12名和正常对照16名,利用新异Oddball模式诱发并记录听觉事件相关电位P300和新异P300。结果:抑郁症组对靶刺激的反应时间(755±244ms)较正常组明显延长(386±114ms);与正常对照组相比,抑郁症组的顶区P3b(P＜0.01)与额区P3a(P＜0.05)波幅明显降低,额区N2波幅也显著降低(P＜0.01);且患者的P3b潜伏期较正常组延迟(P＜0.05)。结论:抑郁症患者额叶执行功能受损,集中注意及非随意注意能力下降,事件相关电位P300可为其临床诊断和生理机制提供依据。

Objective:To study the characteristic of P300 elicited by the Oddball pattern among the depressed patients.Methods:Twelve untreated young depressed patients and sixteen normal people as a control group participated.Auditory P300 and novel P300 were induced and recorded under the Oddball pattern.Results:The depressed patients’ reaction time(755±244ms) to the target stimuli was significantly longer than that of the control group(386±114ms).As compared with the normal,the depressed patients’ amplitudes of P3b in the parietal(P＜0.01),P3a in the frontal(P＜0.05) and N2 in the frontal lobe(P＜0.01) were significantly lower,and the latency of P3b in the depressed group was distinctively longer(P＜0.05).Conclusion:The dysfunction of frontal lobe is found in the depressed patients,so is the decrease of their ability of the voluntary attention and non-voluntary attention.The P300 could give evidence of clinical diagnosis and physiological mechanism.

基金项目：

全军医药卫生科研基金(01L073)资助

作者简介：

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