中国临床心理学杂志

DRD1基因4个多态性位点与注意缺陷多动障碍的关联分析

作者：高雪屏¹ 苏林雁¹ 赵爱玲² 夏昆³

单位：1. 中南大学湘雅二医院精神卫生研究所湖南长沙 410011
2. 广东省精神卫生研究所广东省人民医院广东广州 510120
3. 中南大学医学遗传学国家重点实验室

分类号：R749.94

出版年,卷(期):页码：2009,17(6):658-660

摘要：

目的：探讨ADHD与DRD1基因4个多态性(G-48A,G-1251C,T-800C和T1403C)单个位点的关系。方法：对138名ADHD患者和119名正常对照进行以下遗传学分析:应用PCR-限制性内切酶分析技术分析4个SNP位点,检测各位点基因型和等位基因频率,经χ²检验比较两组间各位点基因型及等位基因频率的差异。结果：①ADHD组中DRD1基因G-48A多态性-48G/-48G基因型频率明显低于对照组,差异有统计学意义(χ²=4.318,P=0.045)。②ADHD组和对照组在DRD1基因的其他3个多态性位点(G-1251C、T-800C和T1403C)等位基因和基因型频率分布均无统计学差异(P>0.05))。结论：①DRD1基因G-48A多态性与ADHD可能存在关联。-48G/-48G基因型可能是ADHD的保护因素。②DRD1基因的其他三个SNP(G-1251C,T800C和T1403C)与ADHD可能均无关联。

Objective:To investigate the relationship between each of the 4 polymorphisms(G-48A,G-1251C,T-800C and T1403C)in DRD1 gene and attention deficit hyperactivity disorder(ADHD).Methods:139 patients with ADHD and 119 normal controls in Hunan area were involved:The genotype and allele frequencies of every single nucleotide polymorphisms(SNP)of the DRD1 gene in these patients and normal controls were examined with polymerase chain reaction(PCR);the significance for the association was estimated by χ² test.Results:①The frequency of-48G/-48G genotype of the G-48A polymorphism of DRD1 gene was significantly lower in ADHD than that in normal controls.② Between patients with ADHD and normal controls,there were no significant differences in the frequencies of the genotypes and alleles of the three polymorphisms in DRD1 gene.Conclusion:①The G-48A polymorphism of DRD1 gene may be associated with ADHD.The-48G/-48G genotype may be a protective factor of ADHD.②Between ADHD and normal controls,there is no significant association in the three polymorphisms in DRDl gene.

基金项目：

国家自然科学基金(30370521,30570659)

作者简介：

参考文献：

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