中国临床心理学杂志

康复期海洛因依赖男性患者精神症状与视觉诱发电位P₃₀₀的关系

单位：1. 山东省安康医院山东济宁 272051
2. 中南大学湘雅二医院精神卫生研究所湖南长沙 410011

分类号：R395.4

出版年,卷(期):页码：2010,18(4):429-430

摘要：

目的:探讨处于康复期的海洛因依赖男性患者(MPHD)精神症状与视觉诱发电位P₃₀₀(VEP-P₃₀₀)的特点及二者的关系。方法:采用抑郁自评量表(SDS)、焦虑自评量表(SAS)及症状自评量表(SCL-90),对38例MPHD与30例健康对照进行评估,并于1周内测受试前额区(Fz)、中央区(Cz)及顶区(Pz)的VEP-P₃₀₀。结果:除强迫状态、人际关系外,MPHD组SCL-90总分及其各因子、SDS总分及SAS总分均显著高于对照组。MPHD组与对照组VEP-P₃₀₀各指标均无显著差异。SAS、SCL-90总分及SCL-90多个因子与Fz、Cz、Pz点VEP-P₃₀₀的潜伏期呈显著正相关。结论:康复期的MPHD仍存在着抑郁、焦虑情绪以及多种心身症状,心理状况与VEP-P₃₀₀密切相关。

Objective:To explore the feature and relationship of pathological psychology and visual evoked potential P₃₀₀(VEP-P₃₀₀) in male patients with heroin dependence(MPHD) in rehabilitative period.Methods:38 MPHD and 30 healthy controls were evaluated with Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS) and Symptom Checklist 90(SCL-90);and VEP-P₃₀₀ were tested at the forehead zone(Fz),the central zone(Cz) and the parietal zone(Pz) in the following week.Results:Compared with healthy controls,MPHD had significantly higher total scores of SDS,SAS,and higher total and factor scores of SCL-90 except factor obsession-compulsive and interpersonal sensitivity of SCL-90(P<0.05 or P<0.01).When administered drug pictures as targets(DT),there was no significant difference at Fz,Cz and Pz between MPHD and controls(P>0.05).There was significant positive correlation between the total scores of SAS,SCL-90,most factors of SCL-90 and the VEP-P₃₀₀ latent period at Pz,Cz and Pz(P<0.05 or P<0.01).The values of correlation were from 0.32 to 0.48.Conclusion:In rehabilitative period,MPHD still suffered from depressive,anxious mood and multitude psychosomatic symptoms,and VEP-P₃₀₀ shows close correlation with psychological state.

基金项目：

国家重点基础研究专项经费973项目(National Basic Program of China,No:003CB515400);2004中南大学研究生教育创新工程项目(040143);山东省济宁市科技局立项课题(200732)

作者简介：

参考文献：

[1] Leshner AI,Addiction is a brain disease. and it matters[J].Science,1997,(5335):45-47.doi:10.1126/science.278.5335.45.
[2] 李武,苏中华,郝伟. 男性海洛因依赖者抑郁特点及影响因素[J].中国行为医学科学,2005,(12):1071-1072,1118.doi:10.3760/cma.j.issn.1674-6554.2005.12.006.
[3] 李武,郝伟,苏中华. 男性海洛因依赖者心身症状与述情特征[J].中国行为医学科学,2005,(10):887-889.doi:10.3760/cma.j.issn.1674-6554.2005.10.009.
[4] 李武,郝伟,胡春凤. 男性海洛因依赖者认知功能状况与氧化应激关系的初步研究[J].中国心理卫生杂志,2007,(03):151-154.doi:10.3321/j.issn:1000-6729.2007.03.004.
[5] Ornstein TJ,Iddon JL,Baldaechino AM. Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers[J].Neuropsychopharmacology:Official Publication of the American College of Neuropsychopharmacology,2000,(02):113-126.
[6] 李武,郝伟,李龙飞. 康复期男性海洛因依赖患者认知功能与视觉诱发电位P300的关系[J].中华精神科杂志,2008,(01):33-36.doi:10.3321/j.issn:1006-7884.2008.01.008.
[7] 李武,郝伟,胡春凤. 男性海洛因依赖者认知功能及相关因素研究[J].中国临床心理学杂志,2007,(02):152-154.doi:10.3969/j.issn.1005-3611.2007.02.013.
[8] 张明圆. 精神科评定量表手册[M].长沙:湖南科学技术出版社,1998.16-27.
[9] 张作记. 中国行为医学科学(特刊)[M].济宁:《中国行为医学科学》杂志社,2001.10.
[10] Lubman DI,Allen N.S,Peters LA. Eleetrophysiological evidence of the motivational salience of drug cues in opiate addiction[J].Psychological Medicine,2007,(08):1203-1209.
[11] 贺忠,周旭辉,王绪轶. 海洛因依赖者停药后脑灰质密度的纵向研究[J].中国临床心理学杂志,2008,(04):358-359.

服务与反馈：

【文章下载】【加入收藏】