中国临床心理学杂志

遭受多重侵害高职高专女生静息态脑功能局部一致性的研究

单位：1. 山东大学护理学院山东济南 250012
2. 国防科学技术大学机电工程与自动化学院湖南长沙 410074
3. 山东大学齐鲁医院山东济南 250012

分类号：R395.2

出版年,卷(期):页码：2012,20(4):451-456

摘要：

目的:探讨遭受多重侵害的高职高专女生静息态脑功能磁共振特点。方法:15名遭受多重侵害无创伤后应激症状被试(PV无PTSS组)、15名多重侵害有创伤后应激症状被试(PV有PTSS组)和15名正常对照接受静息态脑功能扫描。采用SPM8和静息态功能磁共振数据处理工具包分别进行数据预处理和ReHo分析。结果:静息状态下,与对照组相比,PV无PTSS组左侧额下回、左右额内侧回、右侧中央后回、左侧梭状回、左右海马旁回、右侧扣带回、左右豆状核和右侧岛叶的ReHo值降低;左右额上回、左右额中回、左右额下回、左右顶下小叶、左右楔前叶、左右颞上回、左侧颞横回、左右颞中回、右侧舌回和右侧扣带后回的ReHo值升高。与PV有PTSS组相比,PV无PTSS组在右侧额中回和额下回、左侧楔前叶、左侧舌回、左右海马旁回、左侧扣带回和左侧豆状核ReHo值降低;在左右额上回、左右额中回、左侧额内侧回、右侧中央后回、左侧缘上回、左右顶下小叶、左侧梭状回和左侧尾状核ReHo值升高。结论:遭受多重侵害但无创伤后应激症状的高职高专女生在静息状态下脑默认网络以及岛叶、基底神经节、海马旁回存在局部一致性信号异常,这些脑区异常可能为遭受多重侵害导致精神障碍的发病机制提供重要线索。

Objective: To explore the differences of brain spontaneous activity in resting-state between poly-victimized girls and matched controls using a regional homogeneity (ReHo) method. Methods: 15 poly-victimized girls without PTSS,15 poly-victimized girls with PTSS and 15 controls participated in the resting-state fMRI scan. The data preprocessing and analysis were performed by Statistical Parameter Mapping (SPM8) and Resting -State fMRI Data Analysis Toolkit （REST1.6）. Results: Compared with the control group, the PV without PTSS group showed significantly decreased ReHo in the left inferior frontal gyrus, bilateral medial frontal gyrus, right postcentralgyrus, left fusiform gyrus, bilateral parahippocampus,right cingulate gyrus, bilateral lenticular nucleus and right insula; and increased ReHo in the bilateral superior,middle and inferior frontal gyrus, bilateral inferior parietal lobe, bilateral precuneus, bilateral superior temporal gyrus, left transverse temporal gyrus, bilateral middle temporal gyrus, right lingual gyrus and right posterior cingulate gyrus. Compared with PV with the PTSS group, the PV without PTSS group showed significantly decreased ReHo in the right middle and inferior frontal gyrus, left precuneus, left lingual gyrus, bilateral parahippocampus, left cingulate gyrus, left lenticular nucleus and left insula, and increased ReHo in the bilateral superior and middle frontal gyrus, left medial frontal gyrus, right postcentralgyrus, left supramarginalgyrus, bilateral inferior parietal lobe, left fusiform gyrus, and left caudate nuclei and left insula. Conclusion: Abnormal spontaneous activity was found in the default mode network, insula, basal ganglia and parahippocampus in poly-victimized vocational college girls. Disturbance in these regions may be the neurological mechnism for the subsequent psychological disorders.

基金项目：

教育部人文社会科学青年基金项目(10YJCXLX001);山东省自然科学基金(ZR2009CM023)

作者简介：

并列第一作者：董方虹,李宝娟

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