设为首页 | 加入收藏
网站首页 本刊简介 编委会 投稿指南 过刊浏览 广告合作 网上订购 下载专区 联系我们  
精神分裂症的认知神经科学治疗研究进展介绍——与记忆有关的任务选取
作者:费召辉1  孙婷婷1  宋小军2  王湘1 
单位:1. 中南大学湘雅二医院医学心理学研究所 湖南长沙410011 
2.
 武警湖南总队心理工作办公室 湖南长沙410003 
关键词:CNTRICS|精神分裂症|认知功能|记忆 
分类号:R749.3
出版年,卷(期):页码:2012,20(1):37-41
摘要:

Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia(CNTRICS)的目的是确立一些认知神经科学领域的新方法和新手段,将其有效的转化到精神分裂症认知功能的临床研究和精神药物的开发之中,并最终改善精神分裂症患者的认知和社会功能。本文介绍了CNTRICS确定的与记忆有关的三个认知结构:执行控制,工作记忆和长时记忆,以及相关的实验范式和研究成果。

The aim of Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) is to identify a set of new Methods and ways in cognitive neuroscience domain, translate them into clinical research of cognition in schizophrenia and psychotropic drug development process, and finally improve cognitive and social function of schizophrenia patients. This article presents three cognitive constructs about memory in CNTRICS:Executive Control, Working Memory and Long-term Memory, and related experiment paradigms and research achievements.

基金项目:
国家自然科学青年基金(30700236);教育部高校博士点基金(20070533067);湖南省科技厅科技计划项目(2010SK3123);中南大学人文社科杰青专项资助(2011RWSK013)
作者简介:
参考文献:

1 Green MF, Nuechterlein KH, Gold JM, et al. Approaching a consensus cognitive battery for clinical trials in schizophre nia:The NIMH -MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry, 2004, 56: 301-307
2 Carter CS, Barch DM. Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia:the CNTRICS initiative. Schizophr Bull, 2007, 33: 1131-1137
3 Deanna MB, Cameron SC, et al. Selecting paradigms from cognitive neuroscience for translation into use in clinical trials:Proceedings of the third CNTRICS meeting. Schizophrenia Bulletin, 2009, 35: 109-114
4 Deanna MB, Todd SB, et al. CNTRICS final task selection:Executive control. Schizophrenia Bulletin, 2009, 35: 115-135
5 Pantelis C, Barber FZ, Barnes TR, et al. Comparison of setshifting ability in patients with chronic schizophrenia and frontal lobe damage. Schizophr Res, 1999, 37: 251-270
6 Clarke HF, Walker SC, Dalley JW, et al. Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific. Cereb Cortex, 2007, 17: 18-27
7 Crofts HS, Dalley JW, Collins P, et al. Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set. Cereb Cortex,2001, 11: 1015-1026
8 Middleton HC, Sharma A, Agouzoul D, et al. Idazoxan potentiates rather than antagonizes some of the cognitive effects of clonidine. Psychopharmacology (Berl), 1999, 145:401-411
9 Cohen JD, Barch DM, Carter C, et al. Context-processing deficits in schizophrenia:Converging evidence from three theoretically motivated cognitive tasks. J Abnorm Psychol,1999, 108: 120-133
10 Donohue SE, Wendelken C, Bunge SA. Neural correlates of preparation for action select as a function of specific task demands. J Cogn Neurosci, 2008, 20: 694-706
11 Polli FE, Barton JJ, Thakkar KN, et al. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain, 2008, 131:971-986
12 Jordi R, Antoni Rodríguez-Fornells, Thomas F Münte, et al.A neurophysiological study of the detrimental effects of alprazolam on human action monitoring. Brain Res CognBrain Res, 2005, 25: 554-565
13 Mansouri FA, Buckley MJ, Tanaka K. Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment. Science, 2007, 318: 987-990
14 Floden D, Stuss DT. Inhibitory control is slowed in patients with right superior medial frontal damage. J Cogn Neurosci,2006, 18: 1843-1849
15 Enticott PG, Ogloff JR, Bradshaw JL. Response inhibition and impulsivity in schizophrenia. Psychiatry Res, 2008,157: 251-254
16 Aron AR, Dowson JH, Sahakian BJ, et al. Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry, 2003, 54: 1465 -1468
17 Eagle DM, Baunez C, Hutcheson DM, et al. Stop-signal reaction-time task performance:Role of prefrontal cortex and subthalamic nucleus. Cereb Cortex, 2008, 18: 178-188
18 Deanna MB, Marc GB, et al. CNTRICS final task selection:Working memory. Schizophrenia Bulletin, 2009, 35: 136 -152
19 Barch D, Carter C, MacDonald A, et al. Context processing deficits in schizophrenia:Diagnostic specificity, four-week course, and relationships to clinical symptoms. J Abnorm Psychol, 2003, 112: 132-143
20 Mac Donald AW III, Carter CS. Event-related fMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia. J Abnorm Psychol, 2003, 112:689-697
21 Goldman-Rakic PS, Muly EC, Williams GV. D1 receptors in prefrontal cells and circuits. Brain Res Rev, 2000, 31:295-301
22 Dias EC, McGinnis T, Smiley JF, et al. Changing plans: Neural correlates of executive control in monkey and human frontal cortex. Exp Brain Res, 2006, 174: 279-291
23 Nee DE, Jonides J, Berman MG. Neural mechanisms of proactive interference -resolution. Neuroimage, 2007, 38:740-751
24 Thompson-Schill SL, Jonides J, Marshuetz C, et al. Effects of frontal lobe damage on interference effects in working memory. Cogn Affect Behav Neurosci, 2002, 2: 109-120
25 Berenbaum H, Kerns JG, Vernon LL, Gomez JJ. Cognitive correlates of schizophrenia signs and symptoms:I.Verbalcommunication disturbances. Psychiatry Res, 2008, 159:147-156
26 Bunge SA, Klingberg T, Jacobsen RB, Gabrieli JD. A resource model of the neural basis of executive working memory.Proc Natl Acad Sci USA, 2000, 97: 3573-3578
27 Cools R, Gibbs SE, Miyakawa A, et al. Working memory capacity predicts dopamine synthesis capacity in the human striatum. J Neurosci, 2008, 28: 1208-1212
28 John DR, Roshan C, et al. CNTRICS final task selection:Long-term memory. Schizophrenia Bulletin, 2009, 35: 197-212
29 Titone D, Ditman T, Holzman PS, et al. Transitive inference in schizophrenia:Impairments in relational memory organization.Schizophr Res, 2004, 68: 235-247
30 Preston AR, Shrager Y, Dudukovic NM, et al. Hippocampal contribution to the novel use of relational information in declarative memory. Hippocampus, 2004, 14: 148-152
31 Ongur D, Cullen TJ, Wolf DH, et al. The neural basis of relational memory deficits in schizophrenia. Arch Gen Psychiatry,2006, 63: 356-365
32 Bunsey M, Eichenbaum H. Conservation of hippocampal memory function in rats and humans. Nature, 1996, 379:255-257
33 Ragland JD, Gur RC, Valdez JN, et al. Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition. Am J Psychiatry, 2005, 162:1840-1848
34 Murray LJ, Ranganath C. The dorsolateral prefrontal cortex contributes to successful relational memory encoding. J Neurosci, 2007, 27: 5515-5522
35 Ninokura Y, Mushiake H, Tanji J. Integration of temporal order and object information in the monkey lateral prefrontal cortex. J Neurophysiol, 2004, 91: 555-560

服务与反馈:
文章下载】【加入收藏
您是第访问者

《中国临床心理学杂志》编辑部
地址:湖南省长沙市中南大学湘雅二医院内, 410011
电 话:0731-85292472    电子邮件:cjcp_china@163.com
本系统由北京博渊星辰网络科技有限公司设计开发 技术支持电话:010-63361626