中国临床心理学杂志

去甲肾上腺素转运体基因多态性与中国南方汉族人群重性抑郁症的关联研究

单位：1. 湖南省人民医院临床心理科湖南长沙410005
2. 中南大学湘雅二医院精神卫生研究所湖南长沙410011
3. 湖南省第二人民医院湖南长沙410007

分类号：R749.4

出版年,卷(期):页码：2012,20(1):29-31

摘要：

目的:探讨去甲肾上腺素转运体(NET)基因多态性与中国南方汉族人群中重性抑郁症患者之间的关系。方法:采用高温连接酶检测反应法,检测254例抑郁症患者和231例正常对照者的NET基因rs5569位点基因型和等位基因分布。结果:①NET基因rs5569位点基因型和等位基因频率在患者组和对照组的分布差异无统计学意义。②携带rs5569TT基因型患者的汉密尔顿抑郁量表(HAMD)睡眠障碍分值显著高于携带CC、CT基因型患者。携带rs5569CC基因型患者的汉密尔顿焦虑量表(HAMA)精神性焦虑因子分值显著低于TT、CT基因型患者。结论:未发现中国南方汉族人群NET基因rs5569多态性与重性抑郁症存在关联但NET基因rs5569多态性可能与症状群中睡眠障碍和精神性焦虑有关联。

Objective: To investigation the association between norepinephrine transporter(NET) gene and major depression in the southern Chinese Han population. Methods: A total of 254 major depressive disorder patients and 231 controls were tested. The ligase detection reaction was used to detect the SNP of rs5569. Results: ①No significant difference was found in genotype and allele frequencies of the SNP of rs5569 between case and control. ②Genotype TT scored significantly higher than genotype CC and CT on sleep disorder under HAMD. Genotype CC scored significantly lower than genotype TT and CT on psychic anxiety under HAMA. Conclusion: There is no association between major depressive disorder in the southern Chinese Han population and the rs5569 of NET gene. But, association is suspected between the rs5569 of NET gene and symptom clusters such as sleep disorder and psychic anxiety.

基金项目：

国家十五攻关课题(2004DA7210A21)

作者简介：

参考文献：

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