中国临床心理学杂志

癫痫患者默认网络的静息态功能磁共振成像研究

单位：1 兰州理工大学计算机与通信学院兰州 730050
2 厦门理工学院福建省高校物联网应用重点实验室厦门 361024
3 兰州军区总医院影像诊断中心兰州 730000

分类号：R395.1

出版年,卷(期):页码：2013,21(3):363-367

摘要：

目的:分析癫痫患者静息态fMRI下默认网络及其潜在结构的变化。方法:对15名临床诊断为原发全身强直痉挛癫痫患者和20名正常志愿者静息态时的fMRI数据进行独立成分分析,依据空间最佳匹配原则挑选独立成分,研究正常被试和癫痫患者的默认网络差异,并选定默认网络中11个脑区构建功能连接网络,运用图论和聚类方法探讨其潜在结构的改变。结果:与正常对照组相比,患者组默认网络的脑区激活普遍下降,功能连接网络发生明显变化,且整个网络呈现出混乱的层次化结构。结论:静息态下癫痫患者的默认网络及潜在的层次化结构发生异常。

Objective: To analyze the default mode network (DMN) and its latent structure of epileptics in resting-state functional magnetic resonance imaging (fMRI). Methods: The resting-state fMRI data of 15 clinically primary epileptics and 20 normal volunteers were analyzed by independent component analysis. We selected independent component accord ing to the best-sit criterion and analyzed the DMN network of grouping sufferers and normal samples. Finally, we con structed a functional connecting network from the chosen 11 encephalic regions in DMN with graph theory and clustering methods. Results: The encephalic region in DMN of sufferers dramatically fell and their functional connectivity network had obvious change along with the whole network presenting disordered hierarchical structure. Conclusion: The DMN and its latent hierarchical structure of epileptics in resting-state present disordered.

基金项目：

国家自然科学基金项目(61065007,61263047);甘肃省自然科学基金(0916RJZA020);兰州理工大学博士基金项目(BS14200901)

作者简介：

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