中国临床心理学杂志

不同戒断期毒品戒断者对金钱奖赏敏感性的ERP研究

单位：1. 北京师范大学心理学院应用实验心理北京市重点实验室北京 100875
2. 北京师范大学认知神经科学与学习国家重点实验室和麦戈文脑科学研究院北京 100875
3. 北京师范大学情绪调节研究中心北京 100875
4. 脑与学习协同创新中心北京 100875
5. 北京市天堂河戒毒康复所北京 102609

关键词：毒品成瘾戒断期金钱奖赏 N2P3

分类号：R749.64

出版年,卷(期):页码：2014,22(4):571-576

摘要：

目的:本研究采用金钱奖赏范式探讨不同戒断时长(短期戒断组:平均2.7个月,中期戒断组:平均19.36个月,长期戒断组:平均49.6个月)的毒品戒断者与正常匹配组,在分辨不同额度的金钱奖赏时认知加工能力的损伤和恢复情况。方法:研究中要求被试在三种不同的奖赏条件(45分,1分,0分)下完成Go/No-go任务。结果:脑电结果表明,对不同额度的金钱奖赏加工时,短期戒断组和中期戒断组的脑区功能受损,表现为其诱发的N2和P3波幅在三种条件下差异都不显著;长期戒断组在奖赏条件下诱发的N2和P3平均波幅显著大于0分条件,但是波幅差异的程度显著低于控制组。结论:长期戒断组和控制组在神经激活模式上存在的差异,表明经过三年以上的戒断后,戒毒人员的脑功能显示出-定水平的恢复,但是仍未恢复至正常水平。

Objective:The current study aimed to explore cognitive function in drug abstainers at different healing phases(short-term abstinence group: average of 2.7 months, medium-term abstinence group: 19.36 per month on average, longterm abstinence group: average of 49.6 months) with a monetary reward task.Methods: This study adopted a monetary reward paradigm.Participants were required to complete the Go/No-go tasks in three different reward gradients(score of 45,1, 0).Results: Electroencephalographic(EEG) results showed that the sensitivity to monetary reward was declined in both short-and medium-term abstinence groups who have no different brain activation on the reaction to three different reward gradients.The brain function of long-term abstinence group showed a certain level of recovery, reflected by smaller difference of P3 and N2 amplitudes to monetary reward gradient compared to the control group.Conclusion: The damage of rewards perception, assessment, and expectation caused by drug addiction can be normalized following a long term post-drug withdrawl.

基金项目：

国家社科基金重大项目(11&ZD187);北京市教育委员会共建项目建设计划(403101);尚善基金的资助

作者简介：

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