中国临床心理学杂志

长期海洛因戒断者的冲突适应能力——来自ERPs的证据

作者：周艳艳任殿强张海波

单位：1. 锦州医科大学人文与管理学院锦州 121000 2. 西乌珠穆沁旗富龙城镇供暖有限责任公司锡林郭勒盟 026200 3. 兰州市公安局强制隔离戒毒所兰州 730100

关键词：海洛因戒断冲突适应 ERP(Event-related potential) N2

分类号：R395.1

出版年,卷(期):页码：2017,25(5):814-819

摘要：

目的：海洛因滥用导致海洛因依赖者认知控制功能损伤，本研究通过使用ERP技术来探究这种损伤在长期物质戒断后的恢复水平。方法：本研究对比参与字母Flanker任务的长期海洛因戒断组和正常组冲突适应能力的时程动态过程。结果：①两组被试在冲突试次上的反应时(RT_(I))均显著长于一致试次(RT_(C))，Flanker冲突效应(RT_(I-C))没有组间差异；进一步检验发现，两组被试的试次间调节的反应时之差(RT_(cI-iI))差异不显著。②对照组在一致-冲突试次(cI)条件下引发的N2平均振幅显著大于冲突-冲突试次条件(iI)，而长期海洛因戒断组N2效应消失。③长期海洛因戒断组在冲动性量表上的得分显著高于对照组。结论：行为和电生理指标出现分离性的结果，即长期海洛因戒断组在反应时上能够较好的解决冲突，但是长期吸食海洛因导致其认知控制功能损伤。

Objective: This research has employed electroencephalography(EEG) to investigate recovery level of the im-paired cognitive control by long-term material withdrawal as there are many studies have shown that heroin abuse leads to the damaged executive function of heroin addicts. This study intends to further explore the recovery level of cognitive func-tion of long-term heroin withdrawal and puts the "adapt" conflict as an effective indicator. Methods: In order to investigat-ed the conflict adaptation of long-term heroin abstainers, a modified equiprobability Flanker task was used to examine 17 heroin abstainers and 15 healthy controls. Results: ①Analyses revealed that all groups RT_(I) were significantly longer than RT_(C). ②Event-related potential(ERP) measurements showed that cI stimuli elicited larger N2 amplitudes than iI stimuli in the control group, furthermore, the N2 effect was not observed in the long-term heroin withdrawal group. ③Moreover, the scores of BIS-11(Barratt Impulsiveness Scale-11) of the experimental group were markedly higher than control groups. Conclusion: The segregation phenomenon between behavioral and neural correlates suggests that long-term heroin abstain-ers can better adapt to the previous conflict which performance at reaction time, but the cognitive control function(e.g. con-flict adaptation) of long-term male heroin abstainers may be damaged by chronic heroin abuse.

基金项目：

作者简介：

参考文献：

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