中国临床心理学杂志

边缘性人格障碍的神经机制研究进展

作者：靳鑫虎雷小霞蚁金瑶

分类号：R395.1

出版年,卷(期):页码：2017,25(4):630-634

摘要：

边缘性人格障碍（Borderline Personality Disorder，BPD）是一种常见的轴Ⅱ类疾病，主要表现为情绪不稳定、冲动、攻击与自身攻击性行为、不稳定的自我认同和紧张的人际关系。由于其高发生率和后果的严重性，BPD已成为目前精神医学界和临床心理学界都相当关注的一个课题。关于BPD的研究已经有了较大进展，目前已经发现了与BPD症状相关的脑区，包括前额叶-边缘系统，主要有眶额皮质（OFC）、腹内侧前额叶皮质（vmPFC）、背外侧前额叶皮质（DLPFC）、前扣带回（ACC）、海马、杏仁核等。本文主要从不安全依恋、童年创伤、冲动和情绪失调等四个方面总结了关于BPD的神经机制方面的相关研究，为BPD进一步的研究提供参考和借鉴。

Borderline Personality Disorder(BPD) is a common axis Ⅱ disorders typified by features such as pervasive instability in the regulation of emotion, self-image, interpersonal relationships and impulse control. Due to its high occurrence rate and bad consequence, BPD has been a subject which is considerably concerned by both the psychiatrist and clinical psychologist. The researchers have found abnormal brain regions related to core symptoms mainly located in the frontallimbic system, including orbitofrontal cortex(OFC), ventromedial prefrontal cortex (vmPFC), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex(ACC), hippocampus, amygdala. In this review, we summarized the results of neural mechanism of insecure attachment, childhood trauma, impulsivity and emotional dysregulation in BPD, trying to provide references for the further research on BPD in the future.

基金项目：

国家自然科学基金（81370034）

作者简介：

参考文献：

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