中国临床心理学杂志

重复经颅磁刺激辅助治疗老年抑郁症的疗效观察

作者：顾培仇玉莹李晓征

单位：天津市安定医院天津 300222

分类号：R395.5

出版年,卷(期):页码：2017,25(3):588-590

摘要：

目的：探讨重复经颅磁刺激（rTMS）辅助治疗老年抑郁症的疗效。方法：选取2015年1月至2016年5月天津市安定医院住院及门诊收治的老年抑郁症60例，按照随机数字法分为对照组及观察组各30例。对照组予药物治疗（口服舍曲林）及心理治疗干预；观察组在对照组基础上加用rTMS辅助治疗。比较两组疗效和不良反应，分别于基线和治疗2周、4周末采用24项汉密尔顿抑郁量表（HAMD-24）及抑郁自评量表（SDS）评估抑郁程度变化。结果：基线、治疗4周末，两组HAMD及SDS评分比较差异均无统计学意义（P>0.05），而在2周末，差异均有显著统计学意义（P<0.01）；对照组2周末与基线比较，HAMD评分无统计学意义（P>0.05），而SDS评分有统计学意义（P<0.05），4周末与基线比较，HAMD及SDS评分均有显著统计学意义（P<0.01）；而观察组2周末、4周末与基线比较HAMD及SDS评分均有显著统计学意义（P<0.01）。两组患者不良反应发生率差异无显著性差异（P>0.05）。结论：重复经颅磁刺激辅助治疗老年抑郁症疗效较好，起效较快，且安全简便，无明显不良反应。

Objective: To explore the clinical efficacy and safety of Repetitive transcranial magnetic stimulation(rTMS) in the treatment of late life depression. Methods: 60 inpatients with late life depression in Tianjin Anding Hospital were enrolled in the study, who were randomized into control group and observation group. Control group received drug therapy (oral sertraline) and psychological intervention, while observation group received rTMS as the adjuvant treatment on the basis of the original treatment. The efficacy and adverse reactions were compared between the two groups before treatment and after 2 and 4 weeks. The Hamilton Depression Rating Scale(HAMD-24) and self rating Depression Scale(SDS) were used to assess the clinical efficacy. Results: At the baseline and 4th week, there was no significant difference in the HAMD and SDS scores between the two groups. At the 2nd week, there were significant differences of HAMD and SDS scores between the two group(P<0.05). Compared with the baseline, SDS score, but not HAMD score, showed significant differences at the 2nd week in control group(P>0.05); In observation group, the HAMD and SDS score at both 2nd and 4th week significantly decreased comparing to the baseline(P<0.05). Adverse events showed no significant differences between two groups. Conclusion: Repetitive transcranial magnetic stimulation as adjuvant treatment of geriatric depression showed better, faster and safer therapeutic effects, as well as less adverse reactions on the geriatric depression.

基金项目：

天津市卫生局科技基金，重点攻关项目（编号：12KG111）

作者简介：

参考文献：

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