中国临床心理学杂志

强迫症模糊情境下决策能力的事件相关电位研究

单位：1. 安徽医科大学医学心理学系合肥 230032 2. 安徽医科大学第一附属医院神经内科合肥 230022 3. 安徽省精神卫生中心合肥 230000

分类号：R395.1

出版年,卷(期):页码：2017,25(6):1043-1047

摘要：

目的：探讨强迫症在模糊情境下的决策能力及自我监控能力。方法：28例强迫症患者接受爱荷华博弈测验（the revised Iowa Gambling Task，IGT），同时利用Neuroscan 64导脑电仪追踪记录其事件相关电位，并与28例正常对照者作比较。结果：①IGT总净得分对照组高于强迫症组，组别效应显著（F=4.15，P=0.047）；强迫症组在block4上的净得分显著低于对照组（t=-2.03，P=0.048），block5（P=0.067）和block6（P=0.052）上得分低于对照组，但未达到统计学差异；②强迫症组FRN原始波（F=4.782，P=0.033）和差异波（输-赢）（F=4.022，P=0.05）波幅均低于对照组，反馈相关脑区活动异常。结论：模糊情境下，强迫症的决策能力及自我监控能力受损；负性反馈后，其自上而下的自我调整能力降低。

Objective:To explore the decision-making ability and self-monitoring ability under ambiguity in patients with obsessive-compulsive disorder(OCD). Methods:Twenty-eight patients with obsessive-compulsive disorder and twen-ty-eight healthy controls, were enrolled in the revised Iowa Gambling Task(IGT), and the event-related potentials were re-corded using the Neuroscan system. Results:The control group was significantly higher than OCD group in IGT net score (F=4.15, P=0.047). The net score of the OCD group on the block 4 was significantly lower than that of the control group(t=-2.03, P=0.048), the group-differences of the net score showed a significant trend on the block5(P=0.067) and block6(P=0.052). In OCD group, the amplitude of the original wave(F=4.782, P=0.033) and differential wave(loss and loss) (F=4.022, P=0.05) of FRN were lower than that in the control group, suggesting that feedback related brain activity abnormalities. Conclusion:OCD patients show decision-making ability and self-monitoring ability impairment under ambiguity. After the error response, the self-adjustment ability of the top-down is dropped.

基金项目：

安徽医科大学博士科研资助项目（编号：XJ201533）；安徽省高校人文社会科学重点研究基地安徽医科大学医学人文研究中心招标项目（SK2016A0489）

作者简介：

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