中国临床心理学杂志

精神分裂症患者吸烟的静息态功能磁共振研究

单位：1. 重庆医科大学附属第一医院精神科重庆 400016 2. 重庆医科大学附属第一医院放射科重庆 400016 3. 国家精神心理疾病临床研究中心长沙 410011

分类号：R395.1

出版年,卷(期):页码：2017,25(6):1039-1042

摘要：

目的：精神分裂症患者高吸烟率的原因尚不明确，静息态功能磁共振是一个比较好的工具来探索该现象的神经影像学机制。方法：采用局部一致性（Regional homogeneity，ReHo）的方法比较吸烟精神分裂症患者和不吸烟精神分裂症患者，以及不吸烟精神分裂症患者和正常不吸烟对照者之间的静息态功能磁共振（fMRI）图像。结果：设P<0.001，与不吸烟精神分裂症患者相比，吸烟精神分裂症患者在左内侧额回ReHo值下降，左侧小脑后叶与左侧舌回ReHo值升高，且吸烟精神分裂症患者左侧小脑后叶的ReHo值与患者每日吸烟支数显著相关（r=0.635，P=0.027）；与正常不吸烟对照组相比，不吸烟精神分裂症患者双侧内侧额回、右侧颞叶、左侧楔叶ReHo值升高，右侧前扣带回、双侧中央后回、双侧丘脑ReHo值下降。结论：吸烟精神分裂症患者存在左侧小脑后叶，左内侧额回与左侧舌回的局部一致性异常，此发现可能有助于我们探索精神分裂症患者人群吸烟的脑影像学机制。

Objective:The mechanism of high rates of smoking in schizophrenia patients is unclear, resting-state fMRI might be an accessible tool to explore this issue. Methods:Regional homogeneity(ReHo) was compared between smokers with schizophrenia and nonsmokers with schizophrenia, as well as between nonsmokers with schizophrenia and normal non-smokers. Results:Compared to smokers with schizophrenia, nonsmokers with schizophrenia showed significantly de-creased ReHo in the left medial frontal gyrus, and increased ReHo in the left Cerebellum Posterior Lobe and Lingual Gyrus (P<0.001). In addition, ReHo in the left Cerebellum Posterior Lobe of smokers with schizophrenia significantly correlated with daily smoking count(r=0.635, P=0.027). Compared to normal nonsmokers controls, nonsmokers with schizophrenia group showed increased ReHo in the bilateral Medial Frontal Gyrus, right Temporal Lobe, left Cuneus, and decreased ReHo in the right Anterior Cingulate, bilateral Postcentra, bilateral Thalamus. Conclusion:Schizophrenia patients with smoking existed ReHo abnormalities in the left Cerebellum Posterior Lobe, left medial frontal gyrus and left lingual gyrus. The find-ings may help to explore neurological mechanism of schizophrenia patients with high rates of smoking.

基金项目：

国家自然科学基金（81571343）；国家科技支撑计划项目（2015BAI13B00）

作者简介：

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