中国临床心理学杂志

重性抑郁症负性信息注意偏向的神经影像学研究进展

作者：武成莉龚慧蒲唯丹

单位：1. 西安电子科技大学心理健康教育中心西安 710076 2. 西安电子科技大学马克思主义学院西安 710076 3. 中南大学湘雅二医院医学心理中心长沙 410011

分类号：R395.1

出版年,卷(期):页码：2018,26(2):234-238

摘要：

重性抑郁障碍（Major Depressive Disorder,MDD）是一种极易复发的严重精神疾病，但MDD易复发的病因学及神经病理学机制至今依然是一个谜。负性情绪信息注意偏向被认为与抑郁的发生、发展与维持有着紧密联系，近期研究证明其无法被药物治疗完全治愈，并始终保持在MDD缓解期，提示其可能是MDD复发的重要影响因素。然而，注意偏向及其神经病理机制如何影响MDD复发仍处于国内外研究的起步阶段。本文对近期的MDD负性信息注意偏向的神经影像学研究进展进行回顾，以期能为理解负性信息注意偏向影响MDD复发的神经病理学机制提供线索与启示。

Major depressive disorder(MDD) is a severe mental disorder with extremely high recurrence, however, the eti-ology and neurophysiopathological mechanism of the MDD recurrence still remains as an enigma. Attentional biases to-wards negative information(ABNI) have been demonstrated as closely related to the occurrence, development and mainte-nance of depression. Early researches mainly focus on the role of ABNI in the development of MDD, recent evidence has shown that the ABNI cannot be attenuated by the anti-depressive drugs and maintains in the remitted MDD patients, sug-gesting the ABNI is involved in the recurrence of MDD. However, it is unclear how the ABNI and its related neuropathologi-cal abnormalities contribute to the MDD recurrence. This study will review the published neuroimaging studies which focus on the ABNI in patients with MDD, hoping to help for understanding the neuropathological mechanism of ABNI involved in the recurrence of MDD.

基金项目：

本研究受中央高校基本科研业务基金项目（20101164755），国家自然科学基金项目（81401125）资助

作者简介：

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