中国临床心理学杂志

青年重性抑郁症静息态大脑低频振幅研究

作者：朱雪玲¹ 陈璐² 袁福来³

单位：1. 国防科学技术大学人文与社会科学学院长沙 410074
2. 中南大学湘雅医院普外科长沙 410008
3. 中南大学湘雅医院健康管理中心长沙 410008

关键词：抑郁症低频振幅静息态fMRI

分类号：R395.1

出版年,卷(期):页码：2016,24(5):805-807

摘要：

目的：采用功能磁共振低频振幅（amplitude of low frequency-fluctuation，ALFF）技术，研究青年重性抑郁症静息态自发脑活动情况。方法：选取首发未服药青年重性抑郁症27例和健康对照组28例，进行静息态功能磁共振扫描。采用ALFF方法分析静息态数据，并随之进行组分析，观察青年重性抑郁症ALFF的异常改变。结果：与健康对照组比较，青年重性抑郁症右侧楔前叶、右侧舌回ALFF值降低（体素水平P<0.03，簇大小>31，AlphaSim校正，对应校正后的P<0.05），没有发现ALFF值升高的脑区。结论：青年重性抑郁症静息态自发脑神经活动呈降低趋势，这些异常的区域可能与抑郁症情感及认知功能障碍相关。

Objective: This study aimed to investigate the resting-state spontaneous brain activity in young adult patients with major depressive disorder(MDD) by use of the approach of amplitude of low frequency-fluctuation(ALFF). Methods: We analyzed resting-state functional magnetic resonance imaging(fMRI) data obtained from 27 first-episode, treatment-naive young adults with MDD and 28 matched healthy control subjects. Analysis of ALFF was used to detect the difference of the spontaneous brain activity between the young patients with MDD and the healthy control. Results: Compared with the healthy control group, patients with MDD showed significantly decreased ALFF in precuneus and lingual gyrus in the right brain(voxel-level P<0.03, cluster size >31 voxels, corresponding to a corrected P<0.05 as determined by AlphaSim correction). No brain areas showed higher ALFF. Conclusion: Decreased resting-sate spontaneous activity of the brain exists in the young adult patients with MDD, which may be related to the emotion and cognitive dysfunction of the MDD.

基金项目：

国家自然科学基金（81301211）；全国优秀博士学位论文作者专项资金资助项目（201411）；湖南省自然科学基金项目（14JJ4001）；2015、2016年湖南省海外人才与智力引进项目

作者简介：

参考文献：

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