中国临床心理学杂志

基于区域的抑郁症默认网络内部功能连接研究

作者：朱雪玲¹ 袁福来²

单位：1. 国防科学技术大学人文与社会科学学院长沙 410074
2. 中南大学湘雅医院健康管理中心长沙 410008

分类号：R395.1

出版年,卷(期):页码：2016,24(2):218-220

摘要：

目的：探讨静息状态下首发重性抑郁症默认网络内部各节点间功能连接状况。方法：采集31例首发重性抑郁症患者、33例健康对照静息态功能磁共振数据，以后扣带回为种子点进行基于体素的时间相关分析，得到默认网络的关键节点。采用基于区域连接的方法分析默认网络内各节点间功能连接系数。结果：与正常对照组比较，抑郁症患者默认网络背内侧前额叶与后扣带回、右顶下小叶功能连接降低，左顶下小叶与右侧海马结构功能连接降低。结论：抑郁症默认网络内部各节点之间功能连接存在异常，这可能是抑郁症的核心病生理特征。

Objective:This paper was to study the functional connectivity(FC) among the regions within the default mode network(DMN) in patients with major depressive disorder at rest. Methods:We analyzed resting-state functional magnetic resonance imaging(fMRI) data obtained from 31 first-episode, treatment-naive young adults with MDD and from 33 matched healthy control subjects. Seed-based analysis with posterior cingulated cortex(PCC) was used to define DMN. Region-wise FC analysis was performed to inspect FC among the regions within the DMN. Results:Compared with the con-trol group, patients with MDD showed significantly decreased FC of dmPFC(dorsal medial prefrontal cortex) with PCC and right inferior parietal cortex(IPL), as well as decreased FC between left IPL and right HF. Conclusion:The abnormal FC among the regions within DMN is the important in the pathophysiological mechanisms of MDD.

基金项目：

国家自然科学基金（81301211）；全国优秀博士学位论文作者专项资金资助项目（201411）；湖南省自然科学基金项目（S2014J504B1786）；2015年湖南省海外人才与智力引进项目

作者简介：

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