中国临床心理学杂志

单、双相抑郁障碍患者大脑灰质体积比较

作者：胡爱民¹ 2 薛志敏¹ 刘哲宁¹ 王鹏³ 贺忠⁴

单位：1. 中南大学湘雅二医院精神卫生研究所长沙 410011
2. 吉首大学医学院吉首 416000
3. 西安市中心医院西安 710000
4. 中南大学湘雅二医院放射科长沙 410011

分类号：R395.1

出版年,卷(期):页码：2016,24(2):191-195

摘要：

目的：检测单、双相抑郁组、健康对照组的脑灰质体积差异，为鉴别单、双相抑郁障碍提供参考。方法：入组单相抑郁患者17例、双相抑郁患者19例及健康对照28例，以基于体素形态学分析对脑结构磁共振图像进行预处理。结果：与健康对照比较，单、双相抑郁障碍显示了右小脑前叶灰质体积显著减少；与另两组被试比较，单相抑郁障碍显示右颞上回灰质体积显著减少；相关分析显示双相抑郁障碍右小脑前叶灰质体积与抑郁量表得分呈负相关。结论：单、双相抑郁障碍以右小脑前叶灰质体积下降为共同特征，而右颞上回灰质体积差异显示了两种疾病神经解剖结构差异。

Objective:The study aimed to explore the difference of brain grey matter volume in patients with unipolar and bipolar depression, which may help distinguishing the two diseases. Methods:The study recruited 17 patients with uni-polar depression, 19 patients with bipolar depression, and 28 healthy controls. Voxel-based morphometry(VBM) was used to preprocess structural images, and grey matter volume was obtained for each subject. Results:Unipolar depression and bi-polar depression showed the abnormal decreased grey matter volume in the right anterior cerebellum lobe. Unipolar depres-sion showed significant decreased grey matter volume in the right superior temporal gyrus compared to bipolar depression and healthy control. Conclusion:The decreased grey matter volume in the anterior cerebellum lobe may be a common neu-ro-substrate for both unipolar and bipolar depression, and the reduced grey matter volume in the right superior temporal gy-rus may specifically contribute to unipolar depression.

基金项目：

湖南省自然科学基金资助项目（13JJ3029）；湖南省自然科学基金项目（2013FJ473）；国家自然科学基金资助项目（81171287）；国家自然科学基金资助项目（81271485）；国家自然科学基金资助项目（81301161）

作者简介：

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