中国临床心理学杂志

首诊强迫症患者工作记忆与血清微量元素的关系

作者：贾艳滨¹ 何婷婷² 谌建² 钟舒明¹ 廖潇潇³ 张姗红² 黄景玉² 赖顺凯³

单位：1. 暨南大学附属第一医院精神医学科广州 510630
2. 暨南大学管理学院广州 510632
3. 暨南大学第一临床医学院广州 510632

分类号：R395.1

出版年,卷(期):页码：2016,24(1):160-163

摘要：

目的:探讨首诊强迫症患者工作记忆特点及其与血清微量元素的关系。方法:采用数字广度、2-back任务、视觉空间位置记忆和Stroop色-字测试分别对33名首发未服药强迫症患者与31名正常对照进行测量,并测定两组被试血清中微量元素铜(Cu)、锌(Zn)、钙(Ca)、磷(P)、镁(Mg)、铁(Fe)的水平。比较患者组与对照组之间工作记忆的差异及工作记忆与微量元素间的相关性。结果:①患者组数字广度顺背、倒背、总分均较正常对照组差;患者组2-back任务、视觉空间位置记忆测试得分低于对照组;患者组Stroop色-词测验中读字色(Stroop-CW)完成时间长于正常对照。②患者组的微量元素Zn含量显著低于对照组。③患者组Y-BOCS得分与血清Zn含量呈负相关;数字广度倒背、总分及2-back任务正确数与血清Zn含量呈正相关。结论:首诊强迫症患者存在工作记忆损害,且患者血清中Zn含量与工作记忆缺陷可能具有密切关联。

Objective: To examine the relationship between working memory and trace elements in drug-naïve patients with obsessive-compulsive disorder(OCD).Methods: 33 first-episode obsessive-compulsive disorder patients and 31 healthy controls performed 4 working memory tasks, including digital span, 2-back, spatial memory and Stroop color test.Results: ①Compared to control group, the patients group showed significantly lower score in digital span tests, 2-back working memory task, and visual space memory test, as well as longer response time in Stroop-CW test.②The trace element Zn was lower than the control group.③The Y-BOCS score of patients group was negatively correlated with the con-tent of Zn.Backward and composite score of digital span test, as well as the score of 2-back task, were positively correlated with the content of Zn in OCD group.Conclusion: Our findings suggest that drug-naïve OCD patients have working memory impairments, which may be closely related to the trace element Zn.

基金项目：

教育部人文社科研究规划基金项目(13YJA190008)

作者简介：

参考文献：

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