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Objective: To examine the criterion validity of Chinese version of the Patient Health Questionnaire 2(PHQ-2-C) among Chinese adolescents. Methods: 1113 junior-and high-school adolescents(aged 11-18 years) completed the PHQ-2-C, the Centre for Epidemiologic Studies of Depression Symptom Scale(CES-D) and Chinese Version of Beck De-pression Inventory-II(BDI-II-C). Among them, 634 youth(mean age: 14.36±1.71 years old) with CES-D total scores≥20(n= 322) and CES-D total scores<20(n=312) who were matched for age and gender, completed a structured diagnostic inter-view with the Schedule for Affective Disorder and Schizophrenia for School-age Children(K-SADS). Diagnoses of depres-sive disorders which include major depressive disorder(MDD) and any other depressive disorders were made in accordance with DSM-IV. Results: ①For detecting MDD and any depressive disorder, a PHQ-2-C score of ≥3 had sensitivity of 88% ~94%, specificity of 73%~76%, areas under receiver operating characteristic(ROC) curve(AUC) of 0.85, positive predict value(PPV) of 16.5%~29.4% and negative predict value(NPV) of 98.2%~99.5%. ②For detecting MDD, the AUC(0.85), specificity(73%) and positive predict value(16.5%) of the PHQ-2-C were significantly lower than the CES-D and BDI-II-C (AUC:0.91~0.92, specificity: 79%~83%; positive predict value: 20.5%~23.0%) while no difference was found in the index-es mentioned above except AUC between PHQ-2-C and CES-D-10. For detecting any depressive disorder, there was no difference in the indexes except sensitivity among PHQ-2-C, CES-D and CES-D-10, whereas the indexes of PHQ-2-C except NPV were lower than BDI-II-C. Conclusion: The PHQ-2-C demonstrated high criterion validity for detecting MDD and any depressive disorder in Chinese adolescents in school settings, which suggested the PHQ-2-C could be recom-mended as a useful tool for the first step in screening adolescent depression in school settings.
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