中国临床心理学杂志

基于稳定的ICA成分探究精神分裂症异常的功能脑区

作者：李静¹ 2 3 赵书俊¹ 周丽⁴ 聂彬彬² 3 王静娟² 3 方纪成¹ 2 3 刘哲宁⁴ 单保慈² 3

单位：1. 郑州大学物理工程学院郑州450001
2. 中国科学院高能物理研究所核技术应用研究中心北京100049
3. 北京市射线成像技术与装备工程技术研究中心北京100049
4. 中南大学湘雅二医院精神卫生研究所长沙410011

分类号：R395.1

出版年,卷(期):页码：2015,23(5):857-860

摘要：

目的:探讨精神分裂症患者显著异常的脑区.方法:对34例正常人对照组和41例精神分裂症患者进行静息状态下的功能磁共振扫描,采用独立成分分析以及其稳定成分的选取相结合来确定具有功能意义的成分,进行正常人与精神分裂症患者之间的双样本t 检验.结果:找到6个可靠性高的独立成分,并筛选出一个具有功能研究意义的成分;确定精神分裂症患者和正常人之间存在功能异常的脑区,即信号减弱的脑区:左侧额中回(MFG)、左侧颞下回(ITG)、左侧眶部额上回(ORBsup)、左侧前扣带和旁扣带脑回(ACG)、右侧前扣带和旁扣带脑回(ACG)和左侧内侧前额叶(MPFC).结论:发现除了ACG的双侧区域皆存在功能异常外,MFG、ITG、ORBsup、MPFC都是只有左侧存在功能异常,说明临床治疗精神分裂症患者时不可忽视脑区不对称性的影响;其次,研究发现功能异常的区域主要集中在前额叶,可能与记忆和自我控制能力的下降相关.

Objective: To determine and investigate dysfunction regions of schizophrenia. Methods: 34 healthy control subjects and 41 patients with schizophrenia participated to complete the functional magnetic resonance imaging scans at the rest state. Independent component analysis combined the selection of stable component to determine the component with functional significance. Two sample t-test was applied to explore the functional connectivity between healthy controls and schizophrenia patients. Results: Six independent components with high reliability, were identified as being with func-tional significance. Functional connectivity was found significantly reduced in schizophrenia in the Middle frontal gyrus, In-ferior temporal gyrus, Orbitofrontal cortex superior, Anterior cingulate gyrus and medial prefrontal gyrus, compared to healthy controls. Conclusion: It finds ACG exist dysfunction in the both side of the whole brain, MFG、ITG、ORBsup and MPFC exist dysfunction on the left. Not only left side but also right side has the regions of abnormal functional. It explains that the effects of brain asymmetry cannot be ignor during the clinical treatment of schizophrenia patients. Secondly, the re-sults of research show that the regions of brain dysfunction mainly concentrate in the prefrontal cortex. It may be associate with the decline of memory and self control.

基金项目：

国家自然科学基金(81201147)

作者简介：

参考文献：

1 Daban C, Amado I, Bourdel MC, et al. Cognitive dysfunctions in medicated and unmedicated patients with recentonset schizophrenia, Journal of psychiatric research, 2005, 39(4): 391-398
2 Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology, 1998, 12(3): 426
3 马丽娟. 精神分裂症患者认知功能障碍的评估与治疗. 医药前沿,2012,2(2):9-10
4 Schneider FC, Royer A, Grosselin A, et al. Modulation of the default mode network is task-dependant in chronic schizophrenia patients. Schizophrenia Research, 2011, 125(2-3): 110-117
5 Venkataraman A, Whitford TJ, Westin CF, et al. Whole brain resting state functional connectivity abnormalities in schizophrenia. Schizophrenia Research, 2012, 139(1-3): 7-12
6 Huang XQ, Lui S, Deng W, et al. Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI. Neuroimage, 2010, 49(4): 2901-2906
7 Yu QB, Sui J, Kiehl KA, et al. State-related functional integration and functional segregation brain networks in schizophrenia. Schizophrenia Research, 2013, 150(2-3): 450-458
8 Meda SA, Stevens MC, Folley BS, et al. Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis. PLoS One, 2009, 4 (11): e7911
9 Zuo XN, Kelly C, Adelstein JS, et al. Reliable intrinsic connectivity networks: Test-retest evaluation using ICA and dual regression approach. Neuroimage, 2010, 49(3): 2163-2177
10 Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proceedings of the National Academy of Sciences, 2006, 103(26): 10046-10051
11 Damoiseaux JS, Rombouts SA, Barkhof F, et al. Consistent resting-state networks across healthy subjects. Proceedings of the National Academy of Sciences, 2006, 103(37): 13848-13853
12 Mantini D, Perrucci MG, Gratta CD, et al. Electrophysiological signatures of resting state networks in the human brain. Proceedings of the National Academy of Sciences, 2007, 104 (32): 13170-13175
13 Liao W, Mantini D, Zhang Z, et al. Evaluating the effective connectivity of resting state networks using conditional Granger causality. Biological Cybernetics, 2010, 102(1): 57-69
14 Di X, Biswal BB. Identifying the default mode network structure using dynamic causal modeling on resting-state functional magnetic resonance imaging. Neuroimage, 2014, 86: 53-59
15 叶淑贞. 精神分裂症患者前额叶的磁共振研究进展. 现代实用医学,2013,25(7):836-837
16 David AS. Auditory hallucinations: phenomenology, neuropsychology and neuroimaging update. Acta Psychiatrica Scandinavica, 1999, 99(395): 95-104
17 Weiss AP, Heckers S. Neuroimaging of hallucinations: a review of the literature. Psychiatry Research, 1999, 92(2-3): 61-74
18 徐静,李德民,聂彬彬. 运用动态因果模型探究精神分裂症异常有效连接. 中国临床心理学杂志,2014,22(6):981-984
19 王一牛,罗跃嘉. 前额叶皮质损伤患者的情绪异常. 心理科学进展,2004,12(2):161-167
20 朱叶,方菁,张蓓. 精神分裂症社会认知功能缺陷的功能影像研究. 中国临床心理学杂志,2014,22(2):232-239

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