中国临床心理学杂志

MAOA 基因型对青少年反馈评估电生理反应的影响

作者：马任贾惠侨明庆森高一点姚树桥

关键词：MAOA 反馈评估 N2 攻击行为

分类号：R395.1

出版年,卷(期):页码：2015,23(4):621-624

摘要：

目的:探讨单胺氧化酶A(MAOA)基因型对健康男性青少年反馈评估过程的影响。方法:对72名健康男性青少年完成简单赌博任务时进行ERP检测,采用N2的波幅作为指标,比较MAOA高活性组与MAOA低活性组青少年反馈评估过程的特点。结果:MAOA低活性组在赌博任务中的N2波幅比MAOA基因高活性组要低。结论:MAOA低活性组被试的反馈评估能力比高活性组要差,这可能是MAOA低活性被试攻击暴力倾向的潜在神经机制。

Objective: The current study was aimed at investigating whether feedback processing in healthy male adoles-cents would be modulated by monoamine oxidase A(MAOA) genotype. Methods: We recorded brain responses in feedback processing with a single outcome gambling(SOG) task using event-related potential(ERP) in 72 healthy male adolescents. We compared the N2 amplitudes in MAOA-L group and those in MAOA-H group to investigate the differences in feedback processing in participants with different genotypes. Results: Compared with MAOA-L group, N2 was significantly more negative in MAOA-H group. Conclusion: We suggested that these findings reflect an impairment of feedback processing in participants with lower MAOA alleles, which may provide a neural mechanism by which participants with the MAOA-L alleles confer risk for aggression and violence.

基金项目：

国家自然科学基金项目资助(81471384)

作者简介：

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