中国临床心理学杂志

clock基因rs3817444多态性与大学生抑郁症、原发性失眠的关联分析

作者：胡义秋¹ 刘双金¹ 朱翠英¹ 刘衔华²

单位：1. 湖南农业大学教育学院、湖南省儿童青少年健康促进研究中心长沙410128
2. 衡阳师范学院教育科学系衡阳421008

分类号：R395.1

出版年,卷(期):页码：2015,23(3):435-438

摘要：

目的:探讨clock基因与大学生抑郁症、原发性失眠的关联。方法:用Snapshot SNP分型技术对88例(其中抑郁睡眠障碍65例)大学生抑郁症患者、55例原发性失眠患者和110名大学生正常对照进行clock基因rs3817444位点分型, 比较三组间该基因多态性基因型和等位基因频率的差异。结果:与对照组相比, 抑郁症组rs3817444多态性的基因型和等位基因的频率差异无统计学意义(P >0.05);与对照组相比, 原发性失眠组rs3817444多态性的等位基因频率差异有统计学意义(P <0.05);对rs3817444多态性三种基因型C/C、A/C、A/A抑郁症和原发性失眠大学生的临床资料比较, 显示各项没有明显差异(P >0.05)。结论:clock基因rs3817444多态性可能与大学生抑郁症的发病无关联, 但与大学生原发性失眠可能关联。

Objective: To explore the association of clock gene with depressions and Primary insomnia. Methods: The clock gene rs3817444 was genotyped by Snapshot SNP technique in 88 depressions(includng 65 depressions with insominia), 55 Primary insomnia and 110 controls. Results: No significant differences for genotype and allete gene in clock gene rs3817444 were observed between depressions and healthy controls(P >0.05), while significant differences for allete gene in clock gene rs3817444 were presented between Primary insomnia and healthy controls(P <0.05); Comparing the depression and the Primary insomnia's clinical data between three genotypes of the rs3817444 polymorphism C/C、A/C、A/A, it showed no significant differences(P >0.05). Conclusion: The clock gene rs3817444 polymorphism may relate to Primary insomnia, but not depressions.

基金项目：

2014年国家社科基金教育学项目"大学生抑郁症易感性:社会心理因素与基因多态性的共同作用"(BBA140047);2013年湖南省教育规划重点项目(XJK013AXL001)成果;2014年湖南省教育厅科研重点项目(14A063)

作者简介：

参考文献：

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