中国临床心理学杂志

广泛性焦虑障碍患者脑扣带回物质代谢特点探究

单位：1. 新疆医科大学第一附属医院心理医学中心乌鲁木齐830000
2. 中南大学湘雅二医院精神卫生研究所长沙41001l
3. 新疆医科大学第一附属医院影像中心乌鲁木齐830000

关键词：广泛性焦虑障碍扣带回 ¹H-MRS

分类号：R395.1

出版年,卷(期):页码：2015,23(1):60-62

摘要：

目的: 检测广泛性焦虑障碍患者(Generalized Anxiety Disorder,GAD)脑扣带回前、后部位相关物质代谢水平,以探究GAD的病理机制。方法: 选符合ICD-10诊断标准的GAD患者19名为实验组,20名条件匹配的健康志愿者为对照组。用磁共振质子波普成像技术(¹H-Magenetic Resonance Spectroscopy,¹H-MRS)对所有入组者行脑扣带回的前、后部位中胆碱化合物(Cho)、肌酸(Cr)、乙酰天冬氨酸(NAA)物质水平测定,并行两组间比较。结果: 患者组右扣带回前部皮质中的Cho、Cr,白质中的Cho、Cr、NAA,左扣带回前部皮质中的NAA,右扣带回后部皮质中的Cho、Cho/Cr,左扣带回后部皮质中的Cho、Cho/Cr及白质中的Cho、Cr、NAA水平均高于对照组,差异均有统计学意义(P <0.05),且物质代谢水平的增高与HAMA评分呈正相关。结论: GAD患者左右脑扣带回前后部白质、皮质物质代谢水平明显增高,且物质代谢水平越高,焦虑症状越明显。

Objective: To examine substance metabolism of anterior and postrior cingulate cortex in patients with generalized anxiety disorder(GAD). Methods: 19 GAD patients and 20 healthy volunteers were scanned using proton magnetic resonance spectroscopic imaging(1H-MRS), The levels of Choline(Cho), Creatine(Cr) and N-acetyl-aspartate(NAA) in anterior and posteior cingulate cortex were measured and compared in two groups. Results: The levels of Cho(9.89±2.40), Cr (8.59±1.71) in the right anterior cingulate cortex, the levels of Cho(7.22±1.2), Cr(5.44±1.68), NAA(12.09±2.3) in right anterior White matter, the levels of Cho(5.58±1.35); Cho/Cr(0.60±0.41) in right posterior cingulate cortex, the levels of Cho(5.3± 1.06); Cho/Cr(0.77±0.17) in left cingulate gyrus and the levels of Cho(6.46±2.37)、Cr(6.52±1.83)、NAA(1.24±2.32) in left posterior white matter were higher than healthy controls(P <0.05). Substance metabolism of anterior and posterior cingulate cortex was positively correlated to the HAMA score. Conclusion: The levels of chemicals metabolism were increased in white matter and gray matter of cingulate cortex.

基金项目：

新疆医科大学第一附属医院科研奖励基金(2010yry23)

作者简介：

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