中国临床心理学杂志

BDNF Val66Met 基因多态性和温暖的教养方式对青少年抑郁的影响

作者：张璠¹ 2 陈杰¹ 李新影¹

单位：1. 中国科学院心理研究所心理健康重点实验室北京100101
2. 中国科学院大学北京100049

关键词：BDNF Val66Met 教养方式青少年抑郁

分类号：R395.1

出版年,卷(期):页码：2015,23(1):52-55

摘要：

目的: 探讨BDNF Val66Met基因多态性与温暖的教养方式对青少年抑郁水平的影响。方法: 采用爱荷华青年和家庭项目(Iowa Youth and Families Project)中教养问卷的温暖维度与儿童抑郁自评量表(Children's DepressionInventory,CDI)分别对838名青少年抑郁症状与父母的教养方式进行测量,在确定被试BDNF Val66Met基因型后,用多重线性回归对测得数据进行分析。结果: 温暖的家庭教养方式与青少年抑郁症状负相关; BDNF Val66Met多态性与青少年抑郁症状无显著相关; BDNF Val66Met多态性与温暖的家庭教养方式的交互作用显著预测青少年抑郁症状: Val等位基因携带者对家庭教养方式更加敏感。结论: 本研究证实了BDNF Val66Met基因多态性与母亲温暖在青少年抑郁症状上存在交互作用,支持Belsky的“不同易感性模型”。

Objective: To test the influence of BDNF Val66Met polymorphism and parental warmth on adolescent depression. Methods: Parental Warmth Scale from Iowa Youth and Families Project and Children's Depression Inventory were adopted to measure parenting warmth and depression level in 838 adolescents. Their BDNF Val66Met genotype was determined by SNP genotyping. Then, Regression analysis was used to analyze the data. Results: Parental warmth was significantly correlated with depressive symptoms, while the interaction between maternal warmth and BDNF Val66Met polymorphism significantly predicted depressive symptoms. Conclusion: These findings support the‘differential-susceptibility’hypothesis, whereby the BDNF Val allele modulates the influence of maternal warmth on depression. Our fingdings suggest that the Val allele carriers(Val/Val and Val/Met) were more susceptible to maternal warmth.

基金项目：

作者简介：

参考文献：

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