中国临床心理学杂志

精神分裂症与抑郁症症状学及神经递质的比较研究

作者：杨志学童修伦赵勇

关键词：

分类号：R395.9

出版年,卷(期):页码：2000,8(3):177-178

摘要：

有关阴性和阳性精神分裂症的生物学研究证实，两个亚型在DA、NE及5-HT等神经递质代谢方面正好呈负相关。这种症状学及生物学的异质性已形成共识。

Objective: To study the relationship between negative schizophrenia and depression on clinic symptoms and neurotransmitter levels. Methods: The levels of NE,DA, 5-HT, MHPG, HVA, and 5-HIAA in CSF were tested in 21 negative schizophrenia and 11 depression patients. ALL patients were evaluated by HAMD and SANS. Results: The HAMD total score was significantly lower in negative schizophrenia than in depression (p<0.01), there was no difference in SANS between the two groups. The NE level was significantly higher in negative schizophrenia than in depression (p<0.05). Conclusion: Specificity and heterogeneity exist in clinic symptoms and neurobiology between negative schizophrenia and depression.

基金项目：

作者简介：

参考文献：

1 金卫东.对阴性症状和阳性症状认识的评价，临床精神医学杂志，1994，4：119
2 Crow TJ.Molecular pathology of schizophrenia:more than one disease prosess?BriMed J,1980,280:66
3 Prosser ES.Depression,parkinsonia symptoms and negative symptoms in schizophrenics treated with neuroleptics.J Nerv Ment Dis,1987,144:934
4 Van Kanmen DP.Impaired noradrenergic transmission in schizophrenia?Life Sci,1984,34:1403
5 Carpenter WT.Treatment of negative symptoms Schizophr Bull,1985,11:440
6 金卫东.精神分裂症：临床，理论，评价.中国中医药出版社，1994
7 Lindenmayer JP.Negative and positive schizophrenic syndromes after the acute phase:a prospective followup.Compr Psychiatry,1986,27:276
8．刘昌永，何慕陶，刘协和，等.内科讲座-精神病.北京：人民卫生出版社，1984
9 沈渔村.精神病学(第三版).北京：人民卫生出版社，1995
10 韩济生，关新民.医用神经生物学.武汉：武汉出版社，1996

服务与反馈：

【文章下载】【加入收藏】