中国临床心理学杂志

不同剂量美沙酮维持治疗患者渴求感与生存质量研究

单位：1. 中南大学公共卫生学院湖南长沙 410078
2. 湖南省疾病预防控制中心湖南长沙 410005

分类号：R395.2

出版年,卷(期):页码：2009,17(3):365-366

摘要：

目的：探讨接受不同剂量水平的美沙酮维持治疗的海洛因成瘾者的"渴求"程度、"生存质量"改善及两者的关系。方法：采用生存质量简表(WHO-QOLBRIEF)、海洛因渴求问卷分别在患者入组治疗时、治疗后6个月随访调查。结果：①接受美沙酮治疗后患者的"渴求"程度降低、服用高剂量美沙酮的患者"渴求"程度改善更为明显；②接受美沙酮治疗后患者生存质量有所改善，但不同剂量组患者"生存质量"改善无差异；③"渴求"和"生存质量"具有负相关关系，而且在治疗前后保持相对稳定，相关系数分别为r1=-0.451；r2=-0.450。结论：高剂量的美沙酮有助于减少患者对"海洛因"等毒品的渴求。渴求感与生存质量存在负相关关系。

Objective: To explore the change of craving and quality of life and the correlation between the drug abusers accepting different dosages of methadone. Methods: The Questionnaire of Craving for Heroin, and QOL-BRIEF were used to measure the level of craving and quality of life when patients just entering the study and 6 months after treatment re spectively. Results: ①The degree of craving decreased after 6 month treatment, especialy for the patients of high-dosage group. ②The QOLs of patietns had been improved after methadone treatment, but there was no difference between the different doseage group patients. ③There were negative correlations between craving and quality of life. The correlation co efficients were 0.451 and 0.450 and kept on steadily before and after treatment. Conclusion: High-dosage methadone can decrease craving. There is negative correlation between craving and quality of life.

基金项目：

第四轮中国全球基金/中英艾滋病项目应用研究(2008OR47)

作者简介：

参考文献：

[1] 尹江宁，张泽华，蔡月芳，等.美沙酮维持治疗对海洛因依赖者生存质量的影响.中国药物依赖性杂志，2006，15(6)：478-480
[2] 刘克菊，郝伟，张瑞岭．海洛因渴求问卷的初步编制．中国心理卫生杂志，2006,26(1)：23-27
[3] Steven WV，John DM，Jodie A，et al.Predictors of retention in methadone programs: A signal detection analysis. Drug and Alcohol Dependence，2006，83(3)：218-224
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[5] 冯怡，张燕敏，王秀华.吸毒者强制戒毒期间 SCL-90动态分析.中国药物滥用防治杂志，2000，6(3)：5-6

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