中国临床心理学杂志

限制活动慢性应激大鼠脑组织NO、N0S含量变化的研究

单位：解放军第三医院陕西宝鸡 721004

关键词：Environmental stress Limbic system Nitric oxid Nitric oxide synthase

分类号：R395.1

出版年,卷(期):页码：2002,10(3):220-221

摘要：

Objective To observe the change in nitric and nitric oxide synthase in limbic system in the rat brain under slow stress.Methods The slow stress condition was induced by restricted movement of rats,during which the level of NO and activity of NOS were measured in hippocampus,prefrontal and hypothalamus.Results The level of NO and activity of NOS of hippocampus,hypothalamus and prefrontal in stress group was significantly higher than that in the control group (P＜0.05).Conclusion The level of NO increased in brain tissues might play a role in stress related disorder.

基金项目：

作者简介：

参考文献：

[1] 郑晖,杨权.慢性应激对海马结构和功能的影响.国外医学精神病学分册,2001,28:162-165
[2] 夏国玲.应激损害大脑.国外医学精神病学分册,2000,27:43-46
[3] 王焕林,余海鹰,催庶,等.精神分裂病人红细胞SOD、GPX及CAT活性的对照研究.中华精神科杂志,1996,27:83
[4] Cadel JL.Free redical mechanisms in the central nervous system:an overview.Int Neurosci,1988,40:13
[5] Vincent SR,Hope BT.Neurons that say NO.TITN,1999,15(3):108
[6] Bradley DY,Zhou J,Smagin GN,et al.Sleep deprivation by the "Flower Pot" technique and spatial reference memory.Physiop Behav,1997,61:249-256

服务与反馈：

【文章下载】【加入收藏】