Objective:To examine correlations between MRI and cognitive changes associated with cerebral infarction.Methods:Using HDS-R and Senior Cognitive Scale,we assessed 101 patients with cerebral infarction during acute to rehabilitation phase.The results were compared with their MRI.Results:At 3 weeks after onset,cognitive impairment was found in 70.3% of the patients.At 6 months after onset,10% recovered to normal,35.6% improved,22.8% worsened,and 42.5% met the criteria of dementia.During acute phase,infarction focus and leukoaraiosis (LA) were related to cognitive impairment P<0.05.During rehabilitation phase,cognitive impairment was related to LA.Conclusion:Cerebral infarcti on results in significant cognitive impairment.LA is the major cause of cognitive impairment associated with cerebral infarction in rehabilitation.

[1] 本间昭.痴呆客观的评价法.脑神经,1993,45;1119-1133
[2] 洪伟,龚耀先.老年认知功能量表手册.长沙湖南医科大学出版社,1988,1-12
[3] Esiri MM,Wilock GK,Morris JH.Neuropathological assessment of the lesions of significance in vascular dementia J Neurol Neurosurgy Psychiatry,1997,63:749-753
[4] Hildebraudt H Sachsenheimer W.Profiles of patients with left prefrontal and left temporal lobe lesion after cerebrovascular infarctions on Callifonia Verbal LEARNING Test-like incideces,J Clin Nenropsychol,1998,20:673-683
[5] Masuo O Mashima S,Kubo K et al,A case of amnestic syndrom caused by subcotical lobe Brain Inj 1999,13:213-216
[6] 崔诚,张天岭,康铭兰,等.不同部位脑血管病人的IQ与MQ比较研究.中国临床心理血杂志2000,8(4):242-243
[7] Esiri MM GK Morris JH Neuropathologic assessment of the lesions of significance in vascular dementia.J Neurol Neurosurgy Psychiatry,1997,63:749-753
[8] 谭忠林,柯永勤,曾国衍,等.脑白质疏松老年人的认知功能.中国神经精神疾病杂志,1999,25(5):257-259
[9] 徐晓云,赵庆杰,李国霖,等.急性缺血性卒中时的认知障碍与血管性痴呆.中国急救医学,1997,17(3)39-41
[10] David L Nynhuis Philip B Gorelick Vascular dementia Acontenpotaty review of epdemiology,diagnosis prevention and treatment Journal of american geriatric 1998,46(11):1437-1448