中国临床心理学杂志

无症状性脑梗死患者认知功能障碍与抑郁和梗死部位的关系

单位：1. 山东省济宁市精神病防治院山东济宁 272051
2. 济宁市第一人民医院

分类号：R395.3

出版年,卷(期):页码：2003,11(1):42-44

摘要：

目的：探讨无症状性脑梗死 (ACI)患者的认知功能障碍与抑郁和梗死部位、数量的关系。方法：选择 5 6例ACI患者作为研究对象，用修订韦氏成人智力量表和记忆量表、汉密顿抑郁量表等方法检测。结果：1.双侧梗死组VIQ、FIQ及MQ显著低于右侧梗死组 (P <0.05～0.1)，左侧梗死组VIQ、FIQ显著低于右侧梗死组；2 .皮质合并皮质下梗死组、皮质梗死组MQ显著低于皮质下梗死组 (P <0.01)；3.多灶梗死组VIQ、PIQ、FIQ及MQ分均显著低于单灶梗死组 (P <0.05～0.01)；4 .抑郁组各智商及MQ显著低于正常组 (P <0.01)，非抑郁组VIQ显著低于正常组 (P<0.05 )。抑郁组MQ显著低于非抑郁组 (P <0.01)，抑郁组和非抑郁组各智商比较未见显著差异。结论：双侧梗死、皮质合并皮质下梗死、多发性梗死及抑郁的患者更易产生认知功能障碍。

Objective:To study the relation between cognitive dysfunction and depression and location of brain infarct in patients with asymptomatic cerebral infarction(ACI).Methods:Fifty-six patients with ACI demonstrated by CT or MRI scan were tested with WAIS-RC,WMS-RC and HAMD. Results:Patients with bilateral infarction had lower verbal intelligence quotient(VIQ), full intelligence quotient (FIQ), and memory quotient(MQ) than patients with right infarction(P< 0.05 or 0.01). MQ in patients with cortex and cortex combined subcortex infarction were significantly lower than those in patients with subcortex infarction(P < 0.01). VIQ, PIQ(Performance IQ), FIQ and MQ in patients with multiple infarction were significantly lower than those in patients with single focus(P < 0.05 or 0.01). Patients with depression had lower IQ andMQ than the normal control(P< 0.01). Patients without depression had lower scores in VIQ than the normal control(P< 0.05). Patients with depression had lower MQ than those without(P < 0.01). There was no significant difference of IQ between patients with depression and those without(P > 0.05). Conclusion: Patients with bilateral infarction, cortex combined subcortex infarction, multiple infarction and depression have more cogn-i tive dysfunction.

基金项目：

济宁市科委立项课题的部分内容

作者简介：

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