中国临床心理学杂志

氟西汀对乳腺癌抑郁症患者生活质量的疗效研究

作者：汤艳清¹ 2 谢光荣² 李艳苓³ 贾丁鑫² 冯晓红² 邱芳⁴ 齐春莲⁵ 冯悦年⁶

单位：1. 中国医科大学医学心理和精神医学教研室沈阳 110001
2. 中南大学湘雅二医院长沙 410011
3. 鞍山市中心医院
4. 中国医科大学附属第二医院普外科
5. 中国医科大学附属第一医院肿瘤科
6. 大连市第三人民医院乳腺科

关键词：乳腺癌抑郁症生活质量氟西汀

分类号：R749.2

出版年,卷(期):页码：2004,12(4):400-402

摘要：

目的：探讨氟西汀对乳腺癌患者抑郁、焦虑症状的疗效及安全性，并全面评价患者用药前后的生活质量。方法：对63例乳腺癌抑郁症患者进行8周的氟西汀治疗，采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HA MA)、副反应量表(TESS)和相关实验室检查评价氟西汀对乳腺癌抑郁症患者抑郁、焦虑的疗效以及安全性，采用世界卫生组织生存质量评定量表(WHOQOL)评价患者用药前后的生活质量。结果：治疗后患者焦虑、抑郁情绪比入组时明显降低(P <；0.01)，有效率分别为65%和52 % ；患者用药期间未出现明显药物副反应；患者生活质量中的生理、心理、独立性三个领域有明显改善。结论：本研究结果显示氟西汀能明显改善乳腺癌患者的抑郁、焦虑症状，起效时间为2～ 4周；治疗期间副反应较少；应用氟西汀治疗患者抑郁症状的同时能明显提高患者的生活质量。

Objective: To study the effect and reliability of fluoxetine on depression and anxiety symptoms in breast cancer patient, and to assess the overall quality of life before and after treatment.Methods:We treated 63 breast cancer patients with depression by use of Fluxetine for 8 weeks, at the same time, evaluated their emotion state, change of quality of life and the adverse effect with HAMD、HAMA、TESS and laboratory tests.Results: After 8 weeks, patients scores of anx iety and depression decreased significantly from the baseline(P<0.01),effective rates were 65% and 52% respectively.Three domains of quality of life(physiology, psychology and independence) became much better than those of baseline(P<0.05).Conclusion: This study shows that fluoxetine can reduce the depression and anxiety symptoms in breast cancer patients, and the react time is to 4 weeks.Fluoxetine with the treatment of depression and enxiety can improve the patients quality of life.

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参考文献：

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