中国临床心理学杂志

强迫症患者神经认知功能研究

单位：1. 中南大学湘雅二院精神卫生研究所湖南长沙410011
2. 深圳市康宁医院广东深圳518003
3. 深圳市人民医院

分类号：R749.7

出版年,卷(期):页码：2005,13(3):337-339

摘要：

目的：探讨强迫症认知功能障碍的特点。方法：采用韦氏记忆量表(WMS)、数字划销测验(NCT)、威斯康星卡片分类测验(WCST)评估记忆、注意、执行功能。结果：强迫症WMS中的1-100、长时记忆、记图、再生、联想、触摸、理解、短时记忆和记忆商均显著性较正常组差。强迫症NCT中的净分、第一、第三、第四、第五阶段划对数和第一、四阶段失误率均显著性较正常组差；强迫症WCST中的总正确数、总错误数、持续性错误、非持续错误均显著性较正常组差。结论：强迫症的长时记忆、短时记忆、记忆商数、注意及执行功能均显著性较正常人差，其瞬时记忆无明显损害。

Objective:To explore the characteristics of cognitive dysfunction in OCD.Methods:Wechsler Memory Scale(WMS),Number cancellation test(NCT),wisconsin card sorting test(WCST) were used to assessed Memory,attention,executive function of OCD patients.Results:OCD patients did significantly worse than normal controls on 1- 100,long- term memory,figure recall,regeneration,association,touch,story,reciting number,and memory quotient (MQ) of WMS.There were no significant differences between two groups on 100- 1,accumulation,recognize and immediate- term memory of WMS.Total score and accurate cancellation scores on the first,third、fourth,fifth cancellation task and error rate on the first,fouth cancellation task of Number cancellation test (NCT) and total corrects,total errors,perseverative errors and random errors of WCST in OCD patients were significant worse than that in normal controls.Conclusion:The performance of OCD patients was significantly worse than normal controls in long- term memory、short- term memory、MQ、attention、 executive function.Immediate- term memory was not impaired in OCD patients.

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参考文献：

[1] Baxter J,Schwartz M.Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessivecompulsive disorder.Arch Gen Psychiatry,1992,49:681-689.
[2] Swedo S,Schapiro M.Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder.Arch Gen Psychiatry,1989,46:518-523.
[3] Baxter J,Schwartz J.Cerebral glucose metabolism in nondrepressed patients with obsessive-compulsive disorder.Am J Psychiatry,1988,145:1560-1563.
[4] Henin A,Savage CR,Rauch SL,et al.Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?Am J Psychiatry,2001,158(1):137-139.
[5] Okasha A,Rafaat M,Mahallawy N,et al.Cognitive dysfunction in obsessive -compulsive disorder.Acta Psychiatrica Scandinavica,2000,101 (4):281-285.
[6] Aycicegi A,Dinn WM,Harris CL,et al.Neuropsychological function in obsessive-compulsive disorder:effects of comorbid conditions on task performance.Eur Psychiatry.2003 Aug;18(5):241-248.
[7] Goodman W,Price L,Rasmussen,et al.The YBOCS (1):development,use and reliability.Arch Gen psychiatry,1998,46:1006-1011.
[8] 龚耀先,等.修订韦氏记忆量表手册.长沙:湖南医科大学,1989.
[9] 杨德森主编.精神医学丛书第一卷,精神医学基础,第一版.长沙:湖南科技出版社,1981.
[10] Heaton RK.Wisconsin card sorting test manual.Florida:psychologial assessment resources,Inc.Odessa,1981.39-52.
[11] Savage CR,Baer L,Keuthen NJ,et al.Organizational strategies mediate nonverbal memory impairment in obsessive-compulsive disorder[J].Biol Psychiatry,1999,45(7):905-916.
[12] 钟杰,聂晶.强迫症患者的执行功能研究.中国临床心理学杂志,2004,12(4):420-423.
[13] Clayton IC,Richards JC,Edwards CJ.Selective attention in obsessive-compulsive disorder.J Abnorm Psychol,1999,108(1):171-175.
[14] Rossion B,Gauthier I,Tarr MJ,et al.The N170 occipito-temporal component is delayed and enhanced to inverted faces but not to inverted objects:an electrophysiological account of face-specific processes in the human brain.Cognitive M uroscience,2002,111(117):69-74.

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