中国临床心理学杂志

多巴胺D2受体-141C Ins/Del多态与海洛因渴求的关系

作者：邵春红¹ 2 江开达² 李一峰¹ 2 3 赵敏² 林灵¹ 2 3 徐一峰² 王秋颖²

单位：1 .复旦大学附属华山医院精神科上海200040
2. 上海市精神卫生中心上海200030
3. 复旦大学生命学院遗传所

分类号：R749.61

出版年,卷(期):页码：2005,13(3):309-311

摘要：

目的：探讨多巴胺D2受体-141CIns/Del基因多态与线索诱发海洛因渴求程度的关系。方法：对戒断期380名海洛因依赖者实施线索诱发渴求实验，采用PCR-RFLP技术检测其DRD₂-141CIns/Del基因多态，比较不同基因型与线索诱发海洛因渴求程度的关系。结果：DRD₂-141CIns/Del三种多态基因型中，线索暴露前后海洛因渴求程度的差异均无显著性(P＞0.05)。结论：DRD₂-141CIns/Del基因多态可能与线索诱发海洛因渴求的易感性无关。

Objective:To explore the relationship between DRD₂ - 141C Ins/Del polymorphism and heroin craving.Methods:380 heroin addicts who were under abstinence were given the cue- elicited heroin craving experiment.And then we detected the polymorphism of DRD₂- 141CIns/Del for them by using PCR- RFLP.We compared the relationship between genotypes of DRD₂- 141CIns/Del and heroin craving before and after cue exposure.Results:No significant differ- ence has been found between heroin craving before and after cue- exposure in three genotypes of DRD₂- 141CIns/Del.Conclusion:D₂ receptor gene - 141CIns/Del polymorphisms may have no association with the susceptibility of heroin crav- ing.

基金项目：

上海市卫生局科技发展基金(项目号:01417)

作者简介：

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