中国临床心理学杂志

情感语言语境联想刺激模式的fMRI研究

单位：1. 重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室重庆 400016
2. 重庆医科大学附属第一医院血液内科
3. 重庆医科大学附属第一医院影像科

分类号：R395.1

出版年,卷(期):页码：2006,14(1):100-102

摘要：

目的：建立功能核磁共振成像(functionalMagneticResonanceImage，fMRI)的语言情感刺激模式，探讨阅读联想具有正性情感(PositiveEmotion)及负性情感(NegativeEmotion)的语言时，大脑激活区域的差异。方法：健康志愿者6名，均为在校研究生，以汉语为母语。平面回波序列(EchoPlanarImaging，EPI)，血氧水平依赖法(BloodOxygenationLevel-dependentMRI，BOLD)组块设计(BlockDesign)获取功能成像。嘱受试者注视具有正性或负性情感的二字中文词汇，理解其语义后进行联想。结果：受试者理解率和合作率为100%。受试者报告可以区分出两组任务代表不同的情感。一组产生兴奋、高兴的情绪，甚至想笑；而另一组产生悲伤、难过、不安的情绪。负性语言任务激活的区域较正性语言任务激活的区域广泛。负性任务趋向于双侧激活，主要激活了双侧额上回，额中回，中央前回，顶上小叶，颞上回，颞中回；正性语言任务主要激活了左侧额上回，中央前回，顶上小叶，颞上回，颞下回及小脑。负性语言任务还见到扣带前回、杏仁体、丘脑、尾状核头及胼胝体的激活。正性语言任务及负性语言任务可见到枕叶的双侧激活。结论：情感的处理具有偏侧性。负性情感更易被诱发，并伴随更多的脑区被激活。枕叶可能参与情感处理。

Objective: To explore the different brain areas activated by emotion-positive and emotion-negative word tasks, during the functional magnetic resonance image(fMRI) process.Methods: 6 healthy volunteers, with Han as their mother tongue, were required to think around the given words of either positive emotion or negative emotion.Functional images were collected by BOLD block design.Results: With 100% comprehension and cooperation, the subjects were able to tell two different emotions.The emotion-nagative words were prone to activate more areas than the positive ones, which involved superior frontal gyrus, superior temporal gyrus, superior parietal lobule on both hemisphere.The areas activated by emotion-positive words were mainly left hemisphere dominant.Conclusion: Negative emotion was easier to provoke and more areas were implicated in the process, which lay a basis for the research of patients with emotion and language disorders.

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