中国临床心理学杂志

正常人参数性数字n-back工作记忆任务的去激活网络:fMRI研究

作者：杨桂芬张云亭张权张敬李威

关键词：fMRI 工作记忆 n-back 参数设计

分类号：R395.1

出版年,卷(期):页码：2007,15(5):476-479

摘要：

目的：探讨工作记忆任务诱发去激活(Task induced deactivation，TID)脑区及其意义。方法：正常受试者35名，采用参数性数字n-back任务(n为1、2、3)行fMRI，0back作为对照任务。根据受试者在实验过程中3back任务的行为学表现，将准确率为≥85%的受试者纳入高执行表现正常受试者(High performing normal subjects，HPNS)组。采用SPM2软件进行功能数据预处理、统计分析和结果显示。结果：HPNS中TID脑区包括:前额叶皮层内侧部(medialprefrontal cortex，MPFC)；扣带；右侧额下回(BA47)；双侧颞叶多个脑区。在2back负载水平之内，随着负载增加，TID脑区去激活程度增加，但在2back负载之后，大多TID脑区的去激活呈平台期表现。结论：TID网络的存在对WM任务的正确执行是必须的。

Objective: To explore task induced deactivation (TID) brain regions in WM task and its significance.Methods: 35 normal subjects receiving fMRI with a parametric digit n-back task (n=1, n=2, n=3 task) were employed,with an 0-back control condition. On the basis of behavioral performance of 3 back task in experiment, normal subjects whose accuracy exceeding or equal to 85% were included in high performing normal subjects (HPNS) group.Preprocessing, statistical analysis and result display of functional data were performed by SPM2. Results: For HPNS, task induced deactivation brain regions included: medial prefrontal cortex (MPFC), cingulate, right inferior frontal gyrus(BA47),multiple regions in bilateral temporal lobe. Within the scope of 2 back load level, deactivation of TID brain regionsincreased with increasing load, and most TID regions showed platform manifestation once the 2 back level was exceeded.Conclusion: TID network is essential for accurate performance of WM.

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