Objective:To evaluate the memory, executive function and the contributing factors of them in male patients with heroin dependence(MPHD).Methods:140 MPHD and 75 healthy controls were tested for memory and executive function with Wechsler Memory Scale(WMS)and Modified Wisconsin Card Sorting Test(M-WCST)respectively, and 140 MPHD were assessed with a self-developed questionnaire, Symptom Checklist 90(SCL-90), Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS).Results:The performances of WMS and M-WCST in MPHD were significantly lower than those in healthy controls(P<0.05 or 0.01).In MPHD;age correlated negatively, while the educated years correlated positively with MQ and most indicators in M-WCST tests.Heroin abuse years and times per day, veinous injection use route and the number of previous heroin acute toxicosis et al were significantly correlated to some indexes reflecting cognitive function(P<0.05 or P<0.01).The total score of SCL-90, SDS and SAS correlated negatively with MQ, and total score of SAS correlated negatively with card number sorted rightly, while positively with card number sorted wrongly and number of persistent error of M-WCST(P<0.05 or P<0.01).The experience of "high" at drug use, total score of SDS and the educational level entered the regression equation for memory.The total score of SAS and heroin abuse route entered the regression equation for executive function.Conclusion:MPHD suffered from abnormal memory and executive function.The experience of "high" at drug use, educational years, heroin abuse route, and negative mood may be responsible for impaired cognitive function in MPHD.
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