中国临床心理学杂志

心理行为干预与卵巢癌患者T淋巴细胞亚群的动态变化

作者：刘欣彤¹ 周颖清¹ 谢莉玲²

单位：1. 重庆医科大学护理学院护理系重庆 400016
2. 重庆医科大学附属第一医院妇科重庆 400016

分类号：R395.5

出版年,卷(期):页码：2008,16(3):331-333

摘要：

目的:探讨心理行为干预对卵巢癌患者T淋巴细胞亚群功能影响的动态变化,并进一步探讨心理干预的最佳时间。方法:运用病例对照实验设计,对62例卵巢癌患者进行比较研究。用免疫组化碱性磷酸酶桥联酶标法(A-PAAP)测定心理行为干预前及心理行为干预后一个月、二个月、三个月的T淋巴细胞亚群CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺数值的动态变化。结果:心理行为干预一个月后CD3⁺、CD4⁺有显著性提高;干预2个月后各免疫参数均有显著变化,且干预2个月与3个月相比各免疫参数变化不明显。干预组与对照组相比,不同时间点的各种免疫参数有显著性差异(P＜0.05),干预与时间点见明显的交互作用(P＜0.05),除CD8⁺(P＞0.05)外,两组患者各免疫参数存在显著性差异。结论:心理行为干预可以提高卵巢癌患者T淋巴细胞亚群的免疫功能,且干预2个月后患者免疫功能维持在较高水平。

Objective:To examine the effects of the psychological intervention on immune function in ovarian cancer and further explore the best time.Methods:62 inpatients were randomly assigned to either intervention group or control group.Immune parameter variables in both groups were measured four times(before and 1,2,3 months after psychological intervention).Results:CD3⁺、CD4⁺ were increased significantly after psychological intervention for one month;All immune parameters were increased significantly after psychological intervention for two months,but no significant differences between two and three months.Difference between two groups were significant(P＜0.05) at different time;interaction between intervention and time were also significant(P＜0.05),except CD8⁺,all immune parameters were increased significantly.Conclusion:These data suggest that immune function can be improved in patients with ovarian cancer,which remained at a relatively high level after psychological intervention for two month.

基金项目：

作者简介：

参考文献：

[1] 李建中,吴爱勤,吴彩云.肿瘤患者的心理社会因素与免疫功能的测定.中国心理卫生杂志,2002,16(6):386-389
[2] Ikeda H,Chamoto K,Tsuji T,et al.The critical role of type-1 innate and acquired immunity in tumor immunotherapy.Cancer Sci,2004,95(9):697-703
[3] Oizumi S,Strbo N,Pahwa S,et al.Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxie T lymphocytes.Immtmol,2007,179(4):2310-2317
[4] 殷缨,张盈华,张利朝,等.恶性肿瘤患者T细胞亚群与红细胞免疫功能的变化及其相关性分析.实用癌症杂志,2001,16(2):171-173
[5] 蒋红飞.癌症患者的T淋巴细胞亚群免疫功能的研究.国际检验医学杂志,2006,27(7):660-661
[6] 董增义.恶性肿瘤病人手术及化疗前后T淋巴细胞亚群的变化.齐鲁医学杂志,2003,18(2):131-132
[7] Karin L,Bernhard D,Monkia H,et al.The effectiveness of relaxation training in reducing treatment related symptoms and improving emotional adjustment in acute non-surgical cancer treatment:A meta-analytieal review.Psyeho-oncology,2001,10(6):490-502
[8] 贾玫,陈信义.肿瘤心理神经免疫学研究进展.医学研究通讯,2005,(34)10:63-65
[9] Skírnisdóttir I,Lindborg K,Sorbe B,et al.Adjuvant chemotherapy with carboplatin and taxane compared with single drug carboplatin in early stage epithelial ovarian carcinoma.Oncol Rep,2007,18(5):1249-1256

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