中国临床心理学杂志

阴性及阳性症状为主型精神分裂症患者脑功能网络分析

单位：1. 兰州理工大学计算机与通信学院甘肃兰州 730050
2. 国防科技大学机电工程与自动化学院湖南长沙 410073
3. 中南大学湘雅二医院精神卫生研究所

分类号：R749.3

出版年,卷(期):页码：2009,17(5):575-578

摘要：

目的：研究以阴性症状为主和以阳性症状为主的精神分裂症患者脑功能网络拓扑结构的异同。方法：对14名以阴性症状为主的精神分裂症患者(阴性组)和14名以阳性症状为主的精神分裂症患者(阳性组)在静息状态下功能磁共振图像进行分析，结合复杂网络理论来构建脑功能网络，分析网络拓扑结构，并与14名正常人(对照组)进行比较。结果：三组被试静息状态的脑功能网络都具有小世界网络特性，而与对照组相比，阴性组和阳性组静息状态脑功能网络的小世界特性均有所下降，其中阴性组比阳性组略低。结论：从全局组织结构角度证明了精神分裂症患者脑功能网络发生改变，并且阴性精神分裂症患者与阳性精神分裂症患者存在不同的脑功能网络拓扑结构，提示阴性和阳性精神分裂症可能存在不同的神经生物学基础。

Objective:To compare the differences of topological properties of brain functional networks between the schizophrenics with positive and negative symptoms.Methods:The resting-state fMRI data were obtained from 14 schizophrenics with negative symptoms (negative group), 14 schizophrenics with positive symptoms (positive group) and 14 normal healthy subjects(control group). The brain functional networks were constructed based on the complex network theory, and the topological properties of the networks were analyzed.Results:The brain functional networks had significant small-world properties in the three groups and these properties were reduced in the schizophrenics. The small-world properties were lower in the negative group than in the positive group.Conclusion:The brain functional networks are altered in schizophrenics, and the positive group and negative group have different network topological properties of the brain. These findings suggest that the negative and positive subtype of schizophrenics possibly display different basis of neurobiology.

基金项目：

国家973项目(2007CB311001);国家自然科学基金项目(60771062)

作者简介：

参考文献：

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