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目的:用功能磁共振成像(fMRI)检测精神分裂症患者静息状态固有网络功能连接方面的差异,探讨疾病特异性的生物学标记,为理解疾病机理发病机制和临床诊断提供新线索和依据。方法:对25例精神分裂症患者、25例健康同胞和25例健康对照进行静息状态的fMRI资料采集。结果:精神分裂症患者、健康同胞和健康对照共同的固有网络内两两脑区之间的功能连接比较发现有三条异常功能连接:左侧前额叶背外侧(DLPFC)与右侧额下回(IFG)之间的功能连接,左侧颞下回(ITG)与扣带回后部皮质/楔前叶(PCC/PCu)之间的功能连接,双侧ITG之间的功能连接;LSD法发现,在任务负激活网络(TNN),精神分裂症患者和健康同胞均存在双侧ITG的功能连接升高,而仅精神分裂症患者存在PCC/PCu和左侧ITG的功能连接升高;在任务正激活网络(TPN),仅精神分裂症患者存在左侧DLPFC和右侧IFG的功能连接升高。未发现分属TPN和TNN的两两脑区之间的功能连接差异。结论:精神分裂症患者及其健康同胞均存在固有网络的功能连接升高。精神分裂症的病理生理基础与TNN和TPN的功能连接增强有关。TNN的功能连接升高提示患精神分裂症的风险升高,并与精神分裂症的遗传易感性相关。
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Objective:Using functionality magnetic resonance imaging(fMRI),we examined the functional connectivity difference of intrinsic networks between schizophrenic patients and healthy controls,to investigate the disease-specific biological markers,and to provide new clues and evidences for the understanding of the mechanism and diagnosis of schizophrenia.Methods:Functional images of schizophrenic patients(n=25),their healthy siblings(n=25),and healthy controls(n=25) were acquired by resting state functional MRI.The intrinsic networks(including the TPN and TNN) were constructed for each group and the overlapped intrinsic networks were obtained.Results:Significant connectivity difference of the overlapped intrinsic networks was found between schizophrenic patients,healthy siblings and healthy controls.These were the connectivities between the left DLPFC and right inferior frontal gyrus(IFG),the PCC/PCu and left inferior temporal gyrus(ITG),and the left ITG and right ITG.Post hoc tests(LSD) revealed that in the TNN,patients and siblings shared higher connectivity between the bilateral ITG,while patients alone showed higher connectivity between the PCC/PCu and left ITG.In the TPN,only the patients showed higher connectivity between the left DLPFC and IFG.No significant connectivity difference was found between any two regions from different networks.Conclusion:Schizophrenic patients and heathly siblings share raise of functional connectivity in the intrinsic networks.The pathophysiology of schizophrenia involves raised connectivity of the TPN and TNN.Raised connectivity of the TNN may be associated with the genetic liability for schizophrenia.
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