中国临床心理学杂志

奎硫平合并丙戊酸镁治疗老年精神分裂症急性期的对照研究

作者：顾培汪敬曹江李宝珠

单位：天津安定医院天津 300222

分类号：R395.2

出版年,卷(期):页码：2012,20(4):520-522

摘要：

目的:观察用奎硫平合并丙戊酸镁与单用奎硫平治疗老年精神分裂症急性期的疗效与安全性。方法:将58例老年精神分裂症患者随机分为研究组(奎硫平合并丙戊酸镁组)29例,对照组(奎硫平组)29例,疗程2周。分别于治疗1周末、2周末,用阳性与阴性症状量表(PANSS)及外显攻击行为量表(MOAS)评定治疗效果;用副反应量表(TESS)评估不良反应。结果:在治疗2周末,两组临床疗效差异无统计学意义(P>0.05)。在治疗1周末、2周末,PANSS量表兴奋激越项目评分研究组与对照组比较均有统计学意义(P<0.05);2周末,PANSS量表总分有统计学意义(P<0.05)。在治疗1周末、2周末MOAS量表与治疗前比较两组均有统计学意义(P<0.01);两组间比较,2周末有统计学意义(P<0.01)。治疗后各组TESS量表评分均无显著性(P>0.05)。结论:奎硫平合并丙戊酸镁治疗老年精神分裂症急性期起效快、疗效佳、安全性好。

Objective: To compare the efficacy and safety of quetiapine with sustained-release tablets of magnesium valproate and quetiapine only in treatment of old patients with acute phase of schizophrenia. Methods: A total of 58 old patients with acute phase of schizophrenia were randomly divided into two groups: study group (quetiapine with magnesion valproate group) and control group (quetiapine only), for treatment of two weeks． Positive and Negative Syndrome Scale (PANSS) and Modified Overt Aggression Scales(MOAS) were used to assess the effects before treatment, at the 1st weekend and 2nd weekend． Treatment Emergent Symptom Scale (TESS) was uesd to evaluate side effects. Results: At the second weekend, there had no significant difference on efficacy between the two groups （P>0.05）. At the first weekend and the second weekend, the scores of excitement and agitation of PANSS in the study group were significantly lower than the control group （P<0.05）; At the second weekend, the total score of PANSS in the study group was significantly lower than the control group（P<0.05）. At the first weekend and the second weekend, the scores of MOAS in both groups were significantly lower than those of their baseline; At the second weekend, there had no significant difference between the two groups.There had no significant difference for TESS in both groups. Conclusion: Quetiapine with sustained -release tablets of magnesium valproate should be a fast, effective and safe way to treat old patients with acute phase of schizophrenia．

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