中国临床心理学杂志

不同戒断期海洛因戒断者对药物相关刺激加工偏向的ERP研究

单位：1. 应用实验心理北京市重点实验室(北京师范大学心理学院) 北京 100875
2. 认知神经科学与学习国家重点实验室(北京师范大学) 北京 100875
3. 脑与学习协同创新中心北京 100875
4. 北京市新安劳教所北京 102609
5. 北京市天堂河戒毒康复所北京 102609

关键词：海洛因成瘾戒断时间药物相关刺激晚期慢正成分

分类号：R395.1

出版年,卷(期):页码：2014,22(2):191-196

摘要：

目的:考察不同戒断期海洛因戒断者对药物相关刺激认知加工偏向的损伤与恢复情况。方法:研究分别记录控制组、短期、中期和长期戒断组被试对药物相关刺激和中性刺激反应时的脑电变化。结果:长期组对药物相关刺激的反应引起的SPW波幅显著大于中性刺激,而控制组、短期组和中期组对两类刺激反应时诱发的SPW波幅没有显著差异。结论:随着戒断进行,海洛因戒断者对药物相关刺激仍然存在认知加工偏向,不过戒断者所处的社会状态、药物可得性等因素能够对这种强化了的认知加工产生抑制作用。

Objective: Previous studies have shown that drug addiction is usually accompanied by altered brain function, which was considered related to the biased processing on drug-related stimuli. However, it is unclear whether the biased processing and its related brian dysfunction can be reversed by abstinence. The present study aimed to explore the characteristics of the neural activities while drug-related stimuli are presented to drug-abstainers during different abstinence stages. Methods: Event-related potential(ERP) was recorded with 11 males in control group, 14 males in short-term drug abstinent group, 14 males in middle-term abstinent group, 15 males in long-term drug-abstinent group. Results: The present data indicated that there were significant differences between the amplitudes of slow positive waveform(SPW) elicited by neutral and drug-related pictures in long-term abstinent group. However, there were no significant differences between the amplitudes of SPW elicited by these two types of pictures in control group, short-term and middle-term abstinent groups. Conclusion: Based on the above results, we concluded that the people with heroin addiction still showed the biased attention to the drug-related stimuli, but it might be modulated by other factors such as drug availabilities.

基金项目：

国家社科基金重大项目(11&ZD187);北京市教育委员会共建项目建设计划资助(北京市吸毒人员情绪调节能力的评估与训练)资助

作者简介：

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