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预期调节疼痛的认知神经机制
作者:姜召彩1 2  王锦琰1  罗非1 
单位:1. 中国科学院心理研究所  北京 100101 
2.
 中国科学院大学  北京 100039 
关键词:预期|疼痛|认知神经机制 
分类号:R395.1
出版年,卷(期):页码:2013,21(6):916-919
摘要:

预期改变个体疼痛体验的过程体现了大脑对疼痛信息加工的"自上而下"的调节。前人的研究发现预期不仅仅影响经典伤害性信息加工网络的活动,也引起认知加工相关脑区的激活。所以近年来研究者们开始关注预期如何调动多层次的心理过程实现对疼痛的调节。本文系统总结了预期调控疼痛涉及的认知神经机制,主要包括启动情绪过程、调控注意分配、改变动机状态以及反馈。另外,本文还简要分析了临床上预期如何参与慢性疼痛的形成与维持。最后,结合已有的研究提出了未来预期调节疼痛认知神经机制的研究方向。

Expectation modulation on individual's pain experience may reflect the"top-down"regulation of pain in the brain. Previous studies have found that expectation not only influences the activities of classic nociceptive information processing network but also activates cognitive-related brain areas. Thus in recent years, researchers have begun to focus on how expectation mobilizes multi-level psychological processes to modulate pain processing. This article summarized the cognitive neural mechanism underlying expectation modulation of pain, including priming emotion processing, regulating at tention allocation, changing motivational state and the feedback process. Additionally, we briefly analyzed how expectation participated in the development and maintenance of clinical chronic pain. Finally, on the basis of existing researches, we discussed the future research direction of cognitive neural mechanism underlying expectation modulation of pain.

基金项目:
国家自然科学基金(31271092);中国科学院知识创新工程(KSCX2-EW-Q-18)资助
作者简介:
参考文献:

1 Price DD. Psychological mechanisms of pain and analgesia.Progress in Pain Research and Management, 1999, 83: 279-284
2 Tulving E. Memory and consciousness. Cognitive Psycholo-gy, 1985, 26: 1-12
3 Ploghaus A, Becerra L, Borras C, et al. Neural circuitry un-derlying pain modulation: Expectation, hypnosis, placebo.Trends in Cognitive Sciences, 2003, 7(5): 197-200
4 Wager TD, Atlas LY, Leotti LA, et al. Predicting individualdifferences in placebo analgesia: Contributions of brain act-ivity during anticipation and pain experience. The Journal ofNeuroscience, 2011, 31(2): 439-452
5 Atlas LY, Bolger N, Lindquist MA, et al. Brain mediators ofpredictive cue effects on perceived pain. The Journal of Neu-roscience, 2010, 30(39): 12964-12977
6 Wager TD, Matre D, Casey KL. Placebo effects in laser-evoked pain potentials. Brain, Behavior, and Immunity,2006, 20: 219–230
7 Craig AD. A new view of pain as a homeostatic emotion. Tr-ends in Neurosciences, 2003, 26: 303-307
8 Benedetti F, Arduino C, Amanzio M. Somatotopic activationof opioid systems by target-directed expectations of analge-sia. The Journal of Neuroscience, 1999, 19: 3639-3648
9 Petrovic P, Carlsson K, Peterson KM, et al. Context depend-ent amygdale deactivation during pain. Journal of CognitiveNeuroscience, 2001, 16(7): 1289-1301
10 Ploghaus A, Narain C, Beckmann CF, et al. Exacerbation ofpain by anxiety is associated with activity in a hippocampalnetwork. The Journal of Neuroscience, 2001, 21: 9896-9903
11 Gray JA, McNaughton N. Anxiolytic action on the behaviour-al inhibition system implies multiple types of arousal contri-bute to anxiety. Journal of Affect Disorder, 2000, 61(3): 161-176
12 Watson A, El-Deredy W, Iannetti GD, et al. Placebo condi-tioning and placebo analgesia modulate a common brain net-work during pain anticipation and perception. Pain, 2009,145(2): 24-30
13 Ploghaus A, Tracey I, Gati JS, et al. Dissociating pain fromits anticipation in the human brain. Science, 1999, 284:1979-1981
14 Carlsson K, Andersson J, Petrovic P, et al. Predictabilitymodulates the affective and sensory-discriminative neuralprocessing of pain. Neuroimage, 2006, 32(4): 1804-1814
15 Van Damme S, Crombez G, Eccleston C. Disengagementfrom pain: The role of catastrophic thinking about pain.Pain, 2004, 107(2): 70-76
16 Villemure C, Bushnell MC. Mood influences supraspinalpain processing separately from attention. The Journal ofNeuroscience, 2009, 29(3): 705-715
17 Brown CA, Seymour B, Boyle Y, et al. Modulation of pain ra-tings by expectation and uncertainty: Behavioral characteris-tics and anticipatory neural correlates. Pain, 2008, 135(3):240-250
18 Clark JA, Brown CA, Jones AK, et al. Dissociating nocicept-ive modulation by the duration of pain anticipation from un-predictability in the timing of pain. Clinical Neurophysiolo-gy, 2008, 119(12): 2870-2878
19 Peyron R, Laurent B, Garcia-Larrea L. Functional imagingof brain responses to pain: a review and meta-analysis. Clin-ical Neurophysiology, 2000, 30: 263-288
20 Legrain V, Damme SV, Eccleston C, et al. A neurocognitivemodel of attention to pain: behavioral and neuroimaging evi-dence. Pain, 2009, 144(3): 230-232
21 Buhle JT, Stevens BL, Friedman JJ, et al. Distraction andplacebo: Two separate routes to pain control. PsychologicalSciences, 2012, 23(3): 246-253
22 Boston A, Sharpe L. The role of threat-expectancy in acutepain: Effects on attentional bias, coping strategy effective-ness and response to pain. Pain, 2005, 119(3): 168-175
23 Johnston NE, Atlas LY, Wager TD. Opposing effects of exp-ectancy and somatic focus on pain. PLoS One, 2012, 7(6):e38854
24 Fields HL. Understanding how opioids contribute to rewardand analgesia. Regional Anesthesia and Pain Medicine,2007, 32: 242-246
25 Johansen JP, Fields HL, Manning BH. The affective compo-nent of pain in rodents: direct evidence for a contribution ofthe anterior cingulate cortex. Proceedings of the NationalAcademy of Sciences of the United States of America, 2001,98(14): 8077-8082
26 De la Fuente-Ferna'ndez R, Schulzer M, Stoessl AJ. Place-bo mechanisms and reward circuitry: clues from Parkinson' sdisease. Biological Psychiatry, 2004, 56: 67-71
27 Vase L, Price DD, Verne GN, et al. The contributions of sug-gestion, desire, and expectation to placebo effects in irritablebowel syndrome patients. An empirical investigation. Pain,2003, 105(2): 17-25
28 Scott DJ, Stohler CS, Egnatuk CM, et al. Individual differen-ces in reward responding explain placebo-induced expect-ations and effects. Neuron, 2007, 55: 325-336
29 Scott DJ, Stohler CS, Egnatuk CM, et al. Placebo and noceboeffects are defined by opposite opioid and dopaminergicresponses. Archives of General Psychiatry, 2008, 65: 220-231
30 Allan LG, Siegel S. A signal detection theory analysis of theplacebo effect. Journal of Educational Evaluation for HealthProfessions, 2002, 25(4): 410-420
31 Morton DL, El-Deredy W, Watson A, et al. Placebo analgesia as a case of a cognitive style driven by prior expectation.Brain Research, 2010, 1359: 137-141
32 Geers AL, Weiland PE, Kosbab K, et al. Goal activation, ex-pectations, and the placebo effect. Journal of Personality andSocial Psychology, 2005 89(2):143-159
33 Leknes S, Lee M, Berna C, et al. Relief as a reward: hedonicand neural responses to safety from pain. Plos One, 2011, 6(4): e17870
34 Petrovic P, Kalso E, Petersson KM, et al. A prefrontal non-opioid mechanism in placebo analgesia. Pain, 2010, 150:59-65
35 Seymour B, O' Doherty JP, Koltzenburg M, et al. Opponentappetitive- aversive neural processes underlie predictivelearning of pain relief. Nature Neuroscience, 2005, 8: 1234-1240
36 De Peuter S, Van Diest I, Vansteenwegen D, et al. Under-standing fear of pain in chronic pain: interoceptive fear con-ditioning as a novel approach. The European Journal of Pain,2011, 15(9): 889-894
37 Apkarian AV. Pain perception in relation to emotional learn-ing. Current Opinion in Neurobiology, 2008, 18: 464-468
38 Li SG, Wang JY, Luo F. Adult-age inflammatory pain exper-ience enhances long-term pain vigilance in rats. Plos One,2012, 7: e36767
39 刘衔华, 姚树桥, 赵巍峰, 等. 慢性疼痛抑郁症患者的自传体记忆对照研究. 中国临床心理学杂志, 2010, 18(2): 198-201
40 Vlaeyen JS, Kole-Snijders AJ, Boeren RB, et al. Fear of mo-vement/(re)injury in chronic low back pain and its relation tobehavioral performance. Pain, 1995, 62: 363-372

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