中国临床心理学杂志

5-羟色胺2A受体基因多态性与抗抑郁药物治疗反应的关联研究

作者：杨栋¹ 赵靖平² 喻妍³ 吴仁容²

单位：1 湖南省第二人民医院长沙 410007
2 中南大学湘雅二医院长沙 410011
3 湖南省人民医院长沙 410005

分类号：R395.1

出版年,卷(期):页码：2013,21(1):51-53

摘要：

目的:探讨中国汉族抑郁症患者5-羟色胺2A(5-HT2A)受体基因rs6311多态性与抗抑郁药物疗效的关系。方法:对符合美国《诊断与统计手册:精神障碍》第四版(DSM-IV)重性抑郁障碍诊断标准的121例抑郁症患者予以艾司西酞普兰或帕罗西汀治疗,疗程6周。采用高温连接酶检测反应法(LDR)检测5-HT_2A受体基因rs6311位点,分析其与抗抑郁药物疗效的关系。结果:①5-HT_2A受体基因rs6311位点T等位基因、TT基因型在无效组的频率显著高于有效组(P<0.05)。②携带rs6311位点TT基因型患者的汉密尔顿抑郁量表(HAMD)减分值和减分率均显著低于携带CC基因型患者(P<0.05)。结论:5-HT_2A受体基因rs6311位点多态性可能与5-羟色胺再摄取抑制剂(SSRIs)疗效有关,T等位基因、TT基因型可能为疗效差的预测因子。

Objective: To investigation the association between 5HT_2A receptor gene rs6311 polymorphism and antide pressants treatment response of the Han nationality in China.Methods: 121 major depressive disorder patients who met DSMⅣ criterion were given antidepressant drugs for six weeks (escitalopram、paroxetine).5HT_2A receptor gene rs6311 polymorphism was genotyped by the ligase detection reaction.Results: ①The frequencies of T allele and TT genotype of rs6311 were higher in nonresponder group than that in responder group(P<0.05).②The HAMD decreasing score and decreasing score rate of the patients with TT genotype of rs6311 were lower than those with CC genotype of rs6311 (P<0.05).Conclusion: The rs6311 of 5HT_2A receptor gene may be related with the treatment response to SSRIs.Tallele and TT genotype is likely to be a predictive factor of the worse treatment response to SSRIs.

基金项目：

国家十五攻关课题(2004DA7210A21)

作者简介：

参考文献：

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