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抑郁症认知偏向的神经机制研究进展
作者:杨娟1  张小崔2  姚树桥2 
单位:1 海南医学院心理系 海口 571199 
2
 中南大学湘雅二医院医学心理学研究所 长沙 410011 
关键词:抑郁症 注意 记忆 情绪 认知偏向 
分类号:R395.1
出版年,卷(期):页码:2014,22(5):788-791
摘要:

抑郁症是常见的情感性精神障碍,该疾病普遍存在负性认知偏向(负性刺激注意偏向、负性情绪加工偏向及负性刺激记忆偏向等)的特征,且这些认知偏向在抑郁症的发病过程中有重要作用。本文具体从负性刺激注意偏向、负性情绪加工偏向及负性刺激记忆偏向等三个方面阐述了抑郁症认知偏向的神经机制。

Depression is a common psychiatric disorder, and is associated with negative cognitive bias (biased attention for negative stimuli, biased processing of negative emotional stimuli, biased memory for negative stimuli). These cognitive biases are identified as playing an important role in the pathogenesis of depression. In this review, we identify the functional and structural neurobiological architecture of the cognitive bias of depression.

基金项目:
国家自然科学基金地区项目(31360235);海南省人文医学研究基地2014年规划课题(QRYZD201402)资助
作者简介:
参考文献:

1 Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: Results from the national comorbidity survey replication. JAMA, 2003, 289(23): 3095-3105
2 杨文辉,周烃,彭芳,等. 湖南省岳阳县青少年抑郁的流行病学调查.中国临床心理学杂志,2013,21:937-941
3 Beck AT. Depression: Clinical, experimental, and theoretical aqspects. Harper and Row, New York, 1996
4 Gotlib IH, Krasnoperova E, Yue DN, et al. Attentional biases for negative interpersonal stimuli in clinical depression. J Abnorm Psychol, 2004, 113: 121-135
5 朱熊兆,钟明天,蚁金瑶,等. 临床抑郁症患者的注意偏倚特征. 中国临床心理学杂志,2008,16:234-250
6 Hasler G, Drevets WC, Manji HK, et al. Discovering endophenotypes for major depression. Neuropsychopharmacology, 2004, 29: 1765-1781
7 Corbetta M, et al. A common network of functional areas for attention and eye movements. Neuron, 1998, 21: 761-773
8 Beevers CG, Clasen P, Stice E, et al. Depression symptoms and cognitive control of emotion cues: a functional magnetic resonance imaging study. Neuroscience, 2010, 167: 97-103
9 钟明天,朱熊兆,蚁金瑶,等. 抑郁症注意偏倚的研究方法及神经心理学机制. 中国行为医学科学,2008,9:856-858
10 Zhong M, Zhu X, Yi J, et al. Do the early attentional components of ERPs reflect attentional bias in depression? It depends on the stimulus presentation time. Clinical Neurophysiology, 2011, 122: 1371-1381
11 Gotlib IH, Hamilton JP. Neuroimaging and depression: Current status and unresolved issues. Curr Dir Psychol Sci, 2008, 17: 159-163
12 Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci, 2000, 4: 215-222
13 Schaefer HS, Putnam KM, Benca RM, et al. Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre-and post-treatment depression. Biol. Psychiatry, 2006, 60: 974-986
14 Eugene F, Joormann J, Cooney RE, et al. Neural correlates of inhibitory deficits in depression. Psychiatry Res, 2010, 181: 30-35
15 Mathews A, MacLeod C. Cognitive vulnerability to emotional disorders. Annu Rev Clin Psychol, 2005, 1: 167-195
16 Ledoux JE. The emotional brain. Simon and Schuster, New York,1996
17 Santos A, Mier D, Kirsch P, et al. Evidence for a general face salience signal in human amygdala. Neuroimage, 2011, 54: 3111-3116
18 Drevets WC. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol, 2001, 11: 240-249
19 Siegle GJ, Steinhauer SR, Thase ME, et al. Can' t shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry, 2002, 51: 693-707
20 Zhong M, Yao S, Yi J, et al. Elevated amygdala activity to negative faces in young adults with early onset major depressive disorder. Psychiatry Research: Neuroimaging, 2012, 207: 107-112
21 Dannlowski U, et al. Amygdala reactivity predicts automatic negative evaluations for facial emotions. Psychiatry Res, 2007, 154: 13-20
22 Victor TA, Furey ML, Fromm SJ, et al. Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder. Arch Gen Psychiatry, 2010, 67: 1128-1138
23 van Reekum CM, et al. Individual differences in amygdala and ventromedial prefrontal cortex activity are associated with evaluation speed and psychological well-being. J Cogn Neurosci, 2007, 19: 237-248
24 Anand A, Li Y, Wang Y, et al. Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. J Neuropsychiatry Clin Neurosci, 2007, 19: 274-282
25 Schaefer SM, et al. Modulation of amygdalar activity by the conscious regulation of negative emotion. J Cogn Neurosci, 2002, 14: 913-921
26 De Rubeis RJ, Siegle GJ, Hollon SD. Cognitive therapy versus medication for depression: Treatment outcomes and neural mechanisms. Nature Rev Neurosci, 2008, 9: 788-796
27 Li CT, et al. Structural and cognitive deficits in remitting and non-remitting recurrent depression: a voxel-based morphometric study. Neuroimage, 2010, 50: 347-356
28 张小崔,廖坚,朱雪玲,等. 抑郁症认知易感者杏仁核体积的研究. 中国临床心理学杂志,2011,19(1):10-13
29 朱熊兆,钟明天,蚁金瑶,等. 静息状态下未服药首发重性抑郁症患者杏仁核功能连接的研究. 中国临床心理学杂志,2014,22:16-18
30 Siegle GJ, Thompson W, Carter CS, et al. Increased amygdale and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biol Psychiatry, 2007, 61: 198-209
31 Liotti M, Mayberg HS, McGinnis S, et al. Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression. Am J Psychiatry, 2002, 159: 1830-1840
32 Ueda K, et al. Brain activity during expectancy of emotional stimuli: an fMRI study. Neuroreport, 2003, 14: 51-55
33 Grimm S, et al. Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry, 2008, 63: 369-376
34 Hooley JM, Gruber SA, Scott LA, et al. Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants. Biol Psychiatry, 2005, 57: 809-812
35 Greicius MD, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry, 2007, 62: 429-437
36 Holthoff VA, et al. Changes in brain metabolism associated with remission in unipolar major depression. Acta Psychiatr Scand, 2004, 110: 184-194
37 Anand A, et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry, 2005, 57: 1079-1088
38 Nutt D, et al. The other face of depression, reduced positive affect: the role of catecholamines in causation and cure. J Psychopharmacol, 2007, 21: 461-471
39 Watson D, Clark LA, Carey G. Positive and negative affectivity and their relation to anxiety and depressive disorders. J Abnorm Psychol, 1988, 97: 346-353
40 杨新华,刘小群,尹霞云,等. 抑郁症快感缺失概念及其神经生物学基础. 中国临床心理学杂志,2013,21(5):747-750
41 Del Arco A, Mora F. Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex. Pharmacol Biochem Behav, 2008, 90: 226-235
42 Kim SH, Hamann S. Neural correlates of positive and negative emotion regulation. J Cogn Neurosci, 2007, 19: 776-798
43 Heller AS, et al. Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation. Proc Natl Acad Sci USA, 2009, 106: 22445-22450
44 Pizzagalli DA, et al. Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. Am J Psychiatry, 2009, 166: 702-710
45 Tricomi EM, Delgado MR, Fiez JA. Modulation of caudate activity by action contingency. Neuron, 2004, 41: 281-292
46 Koster EH, De Raedt R, Leyman L, et al. Mood-congruent attention and memory bias in dysphoria: Exploring the coherence among information-processing biases. Behav Res Ther, 2010, 48: 219-225
47 Hamilton JP, Gotlib IH. Neural substrates of increased memory sensitivity for negative stimuli in major depression. Biol Psychiatry, 2008, 63: 1155-1162
48 Packard MG, Cahill L, McGaugh JL. Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes. Proc Natl Acad Sci USA, 1994, 91: 8477-8481
49 Steinvorth S, Levine B, Corkin S. Medial temporal lobe structures are needed to re-experience remote autobiographical memories: Evidence from HM and WR. Neuropsychologia, 2005, 43: 479-496
50 蔡赛男,谭长连,等. 抑郁症的功能磁共振研究进展. 中国临床心理学杂志,2013,21(4):535-537
51 姚树桥,刘衔华,赵巍峰,等. 抑郁症患者的自传体记忆研究. 中南大学学报(医学版),2010,35(7):679-684
52 Keedwell PA, Andrew C, Williams SC, et al. A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals. Biol Psychiatry, 2005, 58: 495-503
53 Gibb BE, Schofield CA,Coles ME. Reported history of childhood abuse and young adults' information-processing biases for facial displays of emotion. Child Maltreat, 2009, 14: 148-156

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