Objective: To examine the effect of short term expression writing on stress response in laboratory condition. Methods: 64 4th grade clinical medical students were randomly divided into intervention group and control group. Stress responses were induced by videoes doctor-patient conflicts. After that, state anxiety, negative emotion(such as anger, anxiety, depression and fear), salivary cortisol and posttraumatic growth were assessed. 15 minutes expressive writings included feeling and ideas, express emotion and search for resources and support about stress event was used as the intervention method in writing group for 3 times. The subjects of control group took uninvolved writing. Results: The conflict video induced obvious stress response of subjects, the levels of state anxiety, anger, anxiety, depression and fear scores after video show were significantly higher than that at the baseline in both groups( P <0.01). Both expressive and uninvolved writing significantly decreased the levels of state anxiety, anger, anxiety and fear( P <0.01), but had no effects on depression scores( P > 0.05). Compared with control group, expressive writing group had lower levels of anxiety and anger( P <0.01; P <0.05). Expressive writing had no significant effect on salivary cortisol level and posttraumatic growth( P >0.05). Trait anxiety had positive correlation with state anxiety, anxiety, depression and fear( P <0.001) just after stress-induction, and had positive correlation with state anxiety and depression after intervention( P <0.001). Gender(female) had positive association with state anxiety, depression and fear after stress( P <0.001; P <0.005). Conclusion: Short term expressive writing significantly can decrease stress reactions effciently.
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