中国临床心理学杂志

自闭症早期发现研究进展

作者：徐云杨健

分类号：R395.2

出版年,卷(期):页码：2014,22(6):1023-1027

摘要：

自闭症是一种严重的发育障碍,其患病率急剧上升,病因不明且持续终生,早发现早干预是治疗的关键。本文对针对自闭症儿童社交沟通、语言发展、重复刻板行为以及非典型动作发展等方面回顾性和前瞻性研究的发现进行了总结。这些研究显示,根据早期的社交沟通行为(如不愿意看人脸、对名字缺乏反应、无积极情感、缺乏共同注意等)便可识别出自闭症;语言发育迟缓可以作为自闭症筛查的一个临床指标;但早期的重复行为和非典型动作发展还不能区别自闭症儿童和发育迟缓儿童。未来研究需要结合事件相关电位、磁共振及眼动追踪等新的技术和方法来探究自闭症的早期症状。

Autism is a severe neurodevelopmental disorder which last thourghout a person' s lifetime. Its prevalencehas increased sharply and its cause is unknown. Early recognization and intervention is critical for efficient treatment. This paper mainly discussed the progress of early recognization of children with autism based on social communication, language development, repetitive behavior and atypical motor development. Evidence has suggested that early social communication behavior(e.g., reduced orienting to people' sface, lack of response to name, no positive affection, lack of common attention, etc.) can efficiently recognize early autism and language retardation can be used as a clinical indicator of autism screening. However, inconsistent evidence show that early repetitive behavior and atypical motor development could differentiate between autism and growth retardation. We need to combine new techniques such as event-related potentials, magnetic resonance imaging,eye-tracking and new methods to explore the early markers of autism in the future.

基金项目：

作者简介：

参考文献：

1 Vismara LA, Rogers SJ. The early start denver model: a case study of an innovative practice. Journal of Early Intervent-ion, 2008, 31 (1): 91-108
2 Baio J, Prevalence of autism spectrum disorder among chil-dren aged 8 years. http://www.cdc.gov/mmwr/preview/mmwrh tml/ss6302a1.htm s_cid=ss6302a1_w, 2014-03-28
3 熊妮娜, 杨丽, 于洋. 孤独症、肢体残疾、智力残疾儿童家庭经济负担调查. 中国康复理论与实践, 2010, 16(8): 785-789.
4 Ganz ML. The lifetime distribution of the incremental soci-etal costs of autism. Arch Pediatr Adolesc Med, 2007, 161 (4): 343-349
5 Knapp M, Romeo R, Beecham J. The economic impact of au-tism in Britain. Autism,2009, 13(3): 317-336
6 Dawson G. Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder. Develop-ment and Psychopathology, 2008, 20: 775-803
7 Matson JL, Wilkins J, González M. Early identification and diagnosis in autism spectrum disorders in young children and infants-How early is too early. Research in Autism Spe-ctrum Disorders, 2008, 2: 75-84
8 Hoshino Y, Kaneko M, Yashima Y, et al. Clinical features of autistic children with setback course in their infancy. Japa-nese Journal of Psychiatry and Neurology, 1987, 41(2): 237-245
9 Ohta M, Nagai Y, Hara H, et al. Parental perception of be-havioral symptoms in Japanese autistic children. Journal of Autism and Developmental Disorders, 1987, 17(4): 549-563
10 Short AB, Schopler E. Factors relating to age of onset in au-tism. Journal of Autism and Developmental Disorders, 1988, 18(2): 207-216
11 Adrien JL, Lenoir P, Martineau J, et al. Blind ratings of early symptoms of autism based upon family home movies. Journal of the American Academy of Child and Adolescent Psychia-try, 1993, 32(3): 617-626
12 Baranek GT. Autism during infancy: a retrospective video analysis of sensorymotor and social behaviors at 9-12 mon-ths of age. Journal of Autism and Developmental Disorders 1999, 29(3): 213-224
13 Maestro S, Muratori F, Barbieri F, et al. Early behavioral de-velopment in autistic children: the first 2 years of life thr-ough home movies. Psychopathology, 2001, 34(3): 147-152
14 Lonnie Z, Susan B. Early identification of autism spectrum disorders. Behavioural Brain Research, 2013, 251: 133-146
15 Zwaigenbaum L, Thurm A, Stone W, et al. Studying the em-ergence of autism spectrum disorders in high risk infants: methodological and practical issues. Journal of Autism and Developmental Disorders, 2007, 37: 466-480
16 Deconinck N, Soncarrieu M, Dan B. Toward better recognit-ion of early predictors for autism spectrum disorders. Pediat-ric Neurology, 2013, 49: 225-231
17 Karmel BZ, Gardner JM, Meade LS, et al. Early medical and behavioral characteristics of NICU infants later classified with ASD. Pediatrics, 2010, 126: 457-467
18 Brian J, Bryson SE, Garon N, et al. Clinical assessment of autism inhigh-risk 18-month-olds. Autism, 2008, 12: 433-456
19 Ozonoff S, Macari S, Young GS, et al. Atypical object explo-ration at 12 months of age is associated with autism in a pro-spective sample. Autism, 2008, 12: 457-472
20 Saint-Georges C, Mahdhaoui A, Chetouani M, et al. Do par-ents recognize autistic deviant behavior long before diagno-sis? Taking into account interaction using computational methods. PLoS ONE, 2011, 6(7): e22393
21 Clifford SM, Dissanayake C. The early development of joint attention in infants with autistic disorder using home video observations and parental interview. Journal of Autism and Developmental Disorders, 2008, 38: 791-805
22 Rogers SJ. Developmental regression in autism spectrum disorders. Mental Retardation and Developmental Disabili-ties Research Reviews, 2004, 10(2): 139-143
23 Werner E, Dawson G. Validation of the phenomenon of auti-stic regression using home videotapes. Archives of General Psychiatry, 2005, 62: 889-895
24 Bhat AN, Galloway JC, Landa RJ. Social and non-social vi-sual attention patterns and associative learning in infants at risk for autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 2010, 51: 989-997
25 Ozonoff S, Iosif AM, Baguio F, et al. A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 2010, 49: 256-266
26 Landa RJ, Gross AL, Stuart EA, et al.Developmental traject-ories in children with and without autism spectrum disord-ers: the first 3 years. Child Development, 2012, 84: 429-442
27 Zwaigenbaum L, Bryson S, Rogers T, et al. Behavioral mani-festations of autism in the first year of life. International Jou-rnal of Developmental Neuroscience, 2005, 23: 143-152
28 Landa R, Garret ME. Development in infants with autism spectrum disorders: a prospective study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 2006, 47: 629-638
29 Landa RJ, Gross AL. Latent class analysis of early develop-mental trajectory in baby siblings of children with autism. Journal of Child Psychology and Psychiatry and Allied Dis-ciplines, 2012, 53: 986-996
30 Barbaro J, Dissanayake C. Developmental profiles of infants and toddlers with autism spectrum disorders identified pro-spectively in a community based setting. Journal of Autism and Developmental Disorders, 2012, 42: 1939-1948
31 Werner E, Dawson G, Osterling J, et al. Brief report: recogn-ition of autism spectrum disorder before one year of age: a retrospective study based on home videotapes. Journal of Autism and Developmental Disorders, 2000, 30: 157-162
32 Osterling JA, Dawson G, Munson JA. Earlyrecognition of 1-year-old infants with autism spectrum disorder versus men-tal retardation. Development and Psychopathology, 2002, 14: 239-251
33 Barber AB, Wetherby AM, Chambers NW. Brief report: re-petitive behaviors in young children with autism spectrum disorder and developmentally similar peers: a follow up to watt, et al. Journal of Autism and Developmental Disorders, 2012, 42: 2006-2012
34 Ozonoff S, Macari S, Young GS, et al. Thompson M, Rogers SJ. Atypical object exploration at 12 months of age is associ-ated with autism in a prospective sample. Autism, 2008, 12: 457-472
35 Kanner L. Autistic disturbances of affective contact. Nervous Child, 1943, 2: 217-250
36 Jansiewicz EM, Goldberg MC, Newschaffer CJ, et al. Motor signs distinguish children with high functioning autism and Asperger' s syndrome from controls. Journal of Autism and Developmental Disorders, 2006, 36: 613-621
37 Teitelbaum P, Teitelbaum O, Nye J, et al. Movement analy-sis in infancy may be useful for early diagnosis of autism. Proceedings of the National Academy of Sciences of the Un-ited States of America, 1998, 95: 13982-13987
38 Ozonoff S, Young GS, Goldring S, et al.Gross motor develop-ment, movement abnormalities, and early identification of autism. Journal of Autism and Developmental Disorders, 2008, 38: 644-656
39 Esposito G, Venuti P, Maestro S, et al. An exploration of sy-mmetry in early autism spectrum disorders: analysis of lying. Brain and Development, 2009, 31: 131-138
40 Esposito G, Venuti P. Analysis of toddler' s gait after six months of independent walking to identify autism: a prelimi-nary study. Perceptual and Motor Skills, 2008, 106: 259-269
41 Flanagan JE, Landa R, Bhat A, et al. Head lag in infants at risk for autism: a preliminary study. American Journal of Occupational Therapy, 2012, 66: 577-585
42 Jed TE, Noah J S, Lauren M. Age trends in visual explorat-ion of social and nonsocial information in children with au-tism. Research in Autism Spectrum Disorders, 2012, 6: 842-851
43 Elsabbagh M, Mercure E, Hudry K, et al. Infant neural sens-itivity to dynamic eye gaze is associated with later emerging autism. Current Biology, 2012, 22: 338-342
44 Wolff JJ, Gu H, Gerig G, et al. Differences in white matter fi-ber tract development present from 6 to 24 months in infants with autism. American Journal of Psychiatry, 2012, 169: 589-600

服务与反馈：

【文章下载】【加入收藏】